南方科技大学知识苑(SUSTech KC): A Concise Total Synthesis of (-)-HimalensineA

题名	A Concise Total Synthesis of (-)-HimalensineA
作者	Chen, Yuye1,2,3 ; Hu, Jingping 4; Guo, Lian-Dong1,2 ; Zhong, Weihe1,2 ; Ning, Chengqing1,2,5 ; Xu, Jing1,2
通讯作者	Xu, Jing
发表日期	2019-05-27
DOI	10.1002/anie.201902908
发表期刊	ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 影响因子和分区
ISSN	1433-7851
EISSN	1521-3773
卷号	58 期号:22页码:7390-7394
摘要	The daphniphyllum alkaloids are a structurally fascinating and remarkably diverse family of natural products. General strategies for the chemical synthesis of their challenging architectures are highly desirable for efficiently accessing these intriguing alkaloids and addressing their pharmaceutical potential. Herein, a concise strategy designed to provide general and diversifiable access to various daphniphyllum alkaloids is described and utilized in the asymmetric synthesis of (-)-himalensineA, which was accomplished in 14 steps. Key features of this strategy include a Cu-catalyzed nitrile hydration, a Heck reaction to construct the challenging 2-azabicyclo[3.3.1]nonane motif, a Meinwald rearrangement reaction, six, pot-economic reactions, and the minimal use of protecting groups, which significantly improved the overall synthetic efficiency.
关键词	daphniphyllum alkaloids coupling reaction natural products selective amide reduction total synthesis
相关链接	[来源记录]
收录类别	SCI ; EI ; IC ; CCR
语种	英语
重要成果	NI论文
学校署名	第一 ; 通讯
资助项目	Shenzhen Nobel Prize Scientists Laboratory Project[C17783101]
WOS研究方向	Chemistry
WOS类目	Chemistry, Multidisciplinary
WOS记录号	WOS:000474803100036
出版者	WILEY-V C H VERLAG GMBH
EI入藏号	20191906892907
EI主题词	Alkaloids ; Amides ; Chemical bonds ; Metabolites
EI分类号	Physical Chemistry:801.4 ; Chemical Reactions:802.2 ; Chemical Products Generally:804 ; Organic Compounds:804.1
ESI学科分类	CHEMISTRY
来源库	Web of Science
引用统计	被引频次[WOS]：52
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/25860
专题	理学院_化学系前沿与交叉科学研究院深圳格拉布斯研究院
作者单位	1.Southern Univ Sci & Technol, Dept Chem, Shenzhen, Guangdong, Peoples R China 2.Southern Univ Sci & Technol, Shenzhen Grubbs Inst, Shenzhen, Guangdong, Peoples R China 3.Univ Macau, State Key Lab Qual Res Chinese Med, Inst Chinese Med Sci, Taipa, Macao, Peoples R China 4.Harbin Inst Technol, Sch Chem & Chem Engn, Harbin, Heilongjiang, Peoples R China 5.SUSTech Acad Adv Interdisciplinary Studies, Shenzhen, Guangdong, Peoples R China
第一作者单位	化学系; 深圳格拉布斯研究院
通讯作者单位	化学系; 深圳格拉布斯研究院
第一作者的第一单位	化学系
推荐引用方式 GB/T 7714	Chen, Yuye,Hu, Jingping,Guo, Lian-Dong,et al. A Concise Total Synthesis of (-)-HimalensineA[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2019,58(22):7390-7394.
APA	Chen, Yuye,Hu, Jingping,Guo, Lian-Dong,Zhong, Weihe,Ning, Chengqing,&Xu, Jing.(2019).A Concise Total Synthesis of (-)-HimalensineA.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,58(22),7390-7394.
MLA	Chen, Yuye,et al."A Concise Total Synthesis of (-)-HimalensineA".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 58.22(2019):7390-7394.