Plasma Treatment Conversion of Phenolic Compounds into Fluorescent Organic Nanoparticles for Cell Imaging

Liu, Yong1,2; Yang, Mingzhu1; Li, Juanjuan1; Zhang, Wei1; Jiang, Xingyu1,2,3

2019-05-21

10.1021/acs.analchem.9b00837

ANALYTICAL CHEMISTRY   影响因子和分区

0003-2700

1520-6882

Fluorescent organic nanoparticles (FONs) are promising alternatives for biological imaging applications owing to the increasing concerns over the potential toxicity and poor degradability of inorganic particles-based probes. However, synthesis of stable, small-sized FONs in aqueous media remains challenging. Inspired by the self-polymerization chemistry of phenolic compounds, we demonstrate ultrafast synthesis of FONs (phenolic compound-derived FONs, PhFONs) from a variety of molecular building blocks including dopamine, norepinephrine, pyrogallol, and gallic acid, simply by nontherml plasma treatment at the aqueous interface. Specifically, using dopamine as the precursor, poly(dopamine) (PD)-FONs featuring a small size of 3 nm are obtained within 1 min. Compositional and structural characterizations confirm the polymeric architectures in PD-FONs. The PhFONs, with multicolor emissions, excellent biocompatibility, high stability, and size-dependent access into cell nucleus, are suitable for live cell imaging and developing nucleus-targeting imaging platforms.

SCI ; EI

英语

NI期刊

通讯

Chinese Academy of Sciences[QYZDJ-SSW-SLH039] ; Chinese Academy of Sciences[121D11KYSB20170026]

Chemistry

Chemistry, Analytical

WOS:000469304300049

AMER CHEMICAL SOC

20192106948449

Plasma applications ; Neurophysiology ; Nanoparticles ; Phenols ; Amines ; Fluorescence

Medicine and Pharmacology:461.6 ; Immunology:461.9.1 ; Light/Optics:741.1 ; Nanotechnology:761 ; Organic Compounds:804.1 ; Plasma Physics:932.3 ; Solid State Physics:933

CHEMISTRY

Web of Science

1.Natl Ctr NanoSci & Technol, CAS Ctr Excellence Nanosci, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing Engn Res Ctr BioNanotechnol, 11 Zhongguancun Beiyitiao, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China
3.Southern Univ Sci & Technol, Dept Biomed Engn, 1088 Xueyuan Rd, Shenzhen 518055, Guangdong, Peoples R China

Liu, Yong,Yang, Mingzhu,Li, Juanjuan,et al. Plasma Treatment Conversion of Phenolic Compounds into Fluorescent Organic Nanoparticles for Cell Imaging[J]. ANALYTICAL CHEMISTRY,2019,91(10):6754-6760.

Liu, Yong,Yang, Mingzhu,Li, Juanjuan,Zhang, Wei,&Jiang, Xingyu.(2019).Plasma Treatment Conversion of Phenolic Compounds into Fluorescent Organic Nanoparticles for Cell Imaging.ANALYTICAL CHEMISTRY,91(10),6754-6760.

Liu, Yong,et al."Plasma Treatment Conversion of Phenolic Compounds into Fluorescent Organic Nanoparticles for Cell Imaging".ANALYTICAL CHEMISTRY 91.10(2019):6754-6760.