MiR-107 function as a tumor suppressor gene in colorectal cancer by targeting transferrin receptor 1

Fu, Yuxiang; Lin, Liewen; Xia, Ligang

2019-05-16

10.1186/s11658-019-0155-z

CELLULAR & MOLECULAR BIOLOGY LETTERS   影响因子和分区

1425-8153

1689-1392

BackgroundWhile microRNAs (miRNAs) are known to play a critical role in the progression of colorectal cancer, the role of miR-107 remains unknown. We evaluated its role and explored the underlying mechanism.Materials & methodsMTT, wound-healing, transwell migration and transwell invasion assays were performed to evaluate the role of miR-107 in SW629 cell proliferation, migration and invasion. Real time-PCR and dual-luciferase reporter gene, TFR1 overexpression and western blotting assays were used to explore the underlying mechanism.ResultsMiR-107 is downregulated in colorectal cancer tissues and several human colorectal cancer cell lines. Low miR-107 expression often indicates a poor survival rate for colorectal cancer patients. MiR-107 suppresses the proliferation, migration and invasion of SW620 cells by negatively regulating transferrin receptor 1 (TFR1).ConclusionMiR-107 suppresses the metastasis of colorectal cancer and could be a potential therapy target in colorectal cancer patients.

Colorectal cancer microRNA107 (miR-107) Cancer progress Transferrin receptor 1 (TFR1)

SCI

英语

第一 ; 通讯

Biochemistry & Molecular Biology ; Cell Biology

Biochemistry & Molecular Biology ; Cell Biology

WOS:000468146600002

BMC

MOLECULAR BIOLOGY & GENETICS

Web of Science

South Univ Sci & Technol, Jinan Univ, Dept Gastrointestinal Surg, Shenzhen Peoples Hosp,Clin Med Coll 2,Affiliated, Shenzhen 518055, Peoples R China

Fu, Yuxiang,Lin, Liewen,Xia, Ligang. MiR-107 function as a tumor suppressor gene in colorectal cancer by targeting transferrin receptor 1[J]. CELLULAR & MOLECULAR BIOLOGY LETTERS,2019,24.

Fu, Yuxiang,Lin, Liewen,&Xia, Ligang.(2019).MiR-107 function as a tumor suppressor gene in colorectal cancer by targeting transferrin receptor 1.CELLULAR & MOLECULAR BIOLOGY LETTERS,24.

Fu, Yuxiang,et al."MiR-107 function as a tumor suppressor gene in colorectal cancer by targeting transferrin receptor 1".CELLULAR & MOLECULAR BIOLOGY LETTERS 24(2019).