In vivo actions of Bisphenol F on the reproductive neuroendocrine system after long-term exposure in zebrafish

Qiu, Wenhui1,2,3; Fang, Meijuan1,2; Liu, Jingyu1,2; Fu, Caixia1,2; Zheng, Chunmiao1,2; Chen, Bei3; Wang, Ke-Jian3

2019-05-15

10.1016/j.scitotenv.2019.02.154

SCIENCE OF THE TOTAL ENVIRONMENT   影响因子和分区

0048-9697

1879-1026

Although Bisphenol F (BPF), a bisphenol A (BPA) analogue with a similar chemical structure to that of BPA, is widely used in commercial products, little is known about its potential toxic effects on the reproductive neuroendocrine system in vivo. The present study aimed to comprehensively evaluate the effects of BPF on the reproductive neuroendocrine system in zebrafish and to assess the potential mechanisms underlying its association with estrogen receptor (ER) and aromatase (AROM) pathways. Long-term exposure to environmentally relevant and low levels of BPF led to increased expression of reproductive neuroendocrine-related genes (kiss1, kiss1r, gnrh3, lh beta, and fsh beta) in the zebrafish brain, as well as increased levels of adrenocorticotropic, gonadotropin-releasing, luteinizing, and follicle-stimulating hormones in the zebrafish brain and vitellogenin in the zebrafish liver. In addition, these effects were associated with an increase in er alpha, er beta, cyp19a, and cyp19b activity. Meanwhile, ER and AROM antagonists, alone or in combination, significantly attenuated the stimulation of kiss1, lh beta, vtg, and gnrh3 expression, thereby suggesting that chronic BPF exposure affects the regulation of the reproductive neuroendocrine system through activation of the ER and AROM pathways. Moreover, since BPF and bisphenol S induced toxic and reproductive neuroendocrine effects similar to those of BPA, the current accepted usage of BPA and its analogs should be reconsidered in the future. (c) 2019 Published by Elsevier B.V.

Bisphenol F Reproductive neuroendocrine system Estrogen receptor Enzyme aromatase pathways Zebrafish

SCI ; EI

英语

第一 ; 通讯

Southern University of Science and Technology[G01296001]

Environmental Sciences & Ecology

Environmental Sciences

WOS:000460628600100

ELSEVIER SCIENCE BV

20190806531450

Gene expression

Biology:461.9 ; Organic Compounds:804.1

ENVIRONMENT/ECOLOGY

Web of Science

1.Southern Univ Sci & Technol, Guangdong Prov Key Lab Soil & Groundwater Pollut, Sch Environm Sci & Engn, Shenzhen 518055, Peoples R China
2.Southern Univ Sci & Technol, State Environm Protect Key Lab Integrated Surface, Sch Environm Sci & Engn, Shenzhen 518055, Peoples R China
3.Xiamen Univ, State Key Lab Marine Environm Sci, Xiamen 361005, Fujian, Peoples R China

Qiu, Wenhui,Fang, Meijuan,Liu, Jingyu,et al. In vivo actions of Bisphenol F on the reproductive neuroendocrine system after long-term exposure in zebrafish[J]. SCIENCE OF THE TOTAL ENVIRONMENT,2019,665:995-1002.

Qiu, Wenhui.,Fang, Meijuan.,Liu, Jingyu.,Fu, Caixia.,Zheng, Chunmiao.,...&Wang, Ke-Jian.(2019).In vivo actions of Bisphenol F on the reproductive neuroendocrine system after long-term exposure in zebrafish.SCIENCE OF THE TOTAL ENVIRONMENT,665,995-1002.

Qiu, Wenhui,et al."In vivo actions of Bisphenol F on the reproductive neuroendocrine system after long-term exposure in zebrafish".SCIENCE OF THE TOTAL ENVIRONMENT 665(2019):995-1002.