Ultrasensitive tantalum oxide nano-coated long-period gratings for detection of various biological targets

Piestrzynska, Monika1; Dominik, Magdalena1; Kosiel, Kamil2; Janczuk-Richter, Marta3; Szot-Karpinska, Katarzyna3; Brzozowska, Ewa4; Shao, Liyang5; Niedziolka-Jonsson, Joanna3; Bock, Wojtek J.6; Smietana, Mateusz1,5

2019-05-15

10.1016/j.bios.2019.03.006

BIOSENSORS & BIOELECTRONICS   影响因子和分区

0956-5663

1873-4235

In this work we discussed a label-free biosensing application of long-period gratings (LPGs) optimized in refractive index (RI) sensitivity by deposition of thin tantalum oxide (TaOx) overlays. Comparing to other thin film and materials already applied for maximizing the RI sensitivity, TaOx offers good chemical and mechanical stability during its surface functionalization and other biosensing experiments. It was shown theoretically and experimentally that when RI of the overlay is as high as 2 in IR spectral range, for obtaining LPGs ultrasensitive to RI, the overlay's thickness must be determined with subnanometer precision. In this experiment the TaOx overlays were deposited using Atomic Layer Deposition method that allowed for achieving overlays with exceptionally well-defined thickness and optical properties. The TaOx nano-coated LPGs show RI sensitivity determined for a single resonance exceeding 11,500 nm/RIU in RI range n(D) = 1.335-1.345 RIU, as expected for label-free biosensing applications. Capability for detection of various in size biological targets, i.e., proteins (avidin) and bacteria (Escherichia con), with TaOx-coated LPGs was verified using biotin and bacteriophage adhesin as recognition elements, respectively. It has been shown that functionalization process, as well as type of recognition elements and target analyte must be taken into consideration when the LPG sensitivity is optimized. In this work optimized approach made possible detection of small in size biological targets such as proteins with sensitivity reaching 10.21 nm/log(ng/ml).

Optical fiber sensor Long-period grating Tantalum oxide Atomic layer deposition Label-free biosensing Bacteria detection Protein detection

SCI ; EI

英语

通讯

Poland by the National Science Centre (NCN)[2014/14/E/ST7/00104] ; Poland by the National Science Centre (NCN)[2014/13/B/ST7/01742]

Biophysics ; Biotechnology & Applied Microbiology ; Chemistry ; Electrochemistry ; Science & Technology - Other Topics

Biophysics ; Biotechnology & Applied Microbiology ; Chemistry, Analytical ; Electrochemistry ; Nanoscience & Nanotechnology

WOS:000466248700002

ELSEVIER ADVANCED TECHNOLOGY

20191206664795

Atomic layer deposition ; Chemical stability ; Escherichia coli ; Fiber optic sensors ; Mechanical stability ; Nanosensors ; Optical fibers ; Proteins ; Refractive index

Light/Optics:741.1 ; Fiber Optics:741.1.2 ; Nanotechnology:761 ; Chemistry:801 ; Chemical Products Generally:804 ; Organic Compounds:804.1 ; Solid State Physics:933 ; Crystal Growth:933.1.2

CHEMISTRY

Web of Science

1.Warsaw Univ Technol, Inst Microelect & Optoelect, Koszykowa 75, Warsaw, Poland
2.Inst Electr Mat Technol, Al Lotnikow 32-46, PL-02668 Warsaw, Poland
3.Polish Acad Sci, Inst Phys Chem, Kasprzaka 44-52, PL-01224 Warsaw, Poland
4.Polish Acad Sci, Inst Immunol & Expt Therapy, Rudolfa Weigla 12, PL-53114 Wroclaw, Poland
5.Southern Univ Sci & Technol, Dept Elect & Elect Engn, Shenzhen 518055, Peoples R China
6.Univ Quebec Outaouais, Ctr Rech Photon, 101 Rue St Jean Bosco, Gatineau, PQ J8X 3X7, Canada

Piestrzynska, Monika,Dominik, Magdalena,Kosiel, Kamil,et al. Ultrasensitive tantalum oxide nano-coated long-period gratings for detection of various biological targets[J]. BIOSENSORS & BIOELECTRONICS,2019,133:8-15.

Piestrzynska, Monika.,Dominik, Magdalena.,Kosiel, Kamil.,Janczuk-Richter, Marta.,Szot-Karpinska, Katarzyna.,...&Smietana, Mateusz.(2019).Ultrasensitive tantalum oxide nano-coated long-period gratings for detection of various biological targets.BIOSENSORS & BIOELECTRONICS,133,8-15.

Piestrzynska, Monika,et al."Ultrasensitive tantalum oxide nano-coated long-period gratings for detection of various biological targets".BIOSENSORS & BIOELECTRONICS 133(2019):8-15.