Photoacoustic Imaging of Brain Functions: Wide Filed-of-View Functional Imaging with High Spatiotemporal Resolution

Jin, Tian; Qi, Weizhi; Liang, Xiao; Guo, Heng; Liu, Quanying; Xi, Lei

2021-12-01

10.1002/lpor.202100304

Laser & Photonics Reviews   影响因子和分区

1863-8880

1863-8899

Neuroimaging techniques can reveal complex brain functions associated with behaviors and emotions. However, most existing neuroimaging methods suffer from balancing tradeoffs among the temporal and spatial resolutions as well as the field of view (FOV). A high spatiotemporal resolution photoacoustic neuroimaging (PANI) technique with a wide FOV sufficient to cover the entire mouse cerebral cortex in transverse plane and measure fast neuronal dynamics is developed. Based on the experimental validations from both drug-induced epilepsy and electrical stimulation in the mouse brain, PANI features the following capabilities: i) deriving functional information from the fluctuation of total hemoglobin (HbT) to identify the neural activity and connectivity of the mouse cortex; ii) integrating with other neurological recording methods such as electroencephalograph (EEG) to investigate the neurovascular coupling; and iii) revealing the interactive connectivity between distant brain regions under different physiological conditions. The special features of PANI offer a unique window on investigating the fast neural dynamics with a wide FOV at the capillary scale.

high speed microscopy neuroimaging photoacoustic imaging wide field-of-view

SCI ; EI

英语

第一 ; 通讯

National Natural Science Foundation of China[62022037,61775028,81571722,61528401] ; Department of Science and Technology of Guangdong Province["2019ZT08Y191","SZBL2020090501013"] ; Shenzhen Science and Technology Program["KQTD20190929172743294","JCYJ20200109141222892"]

Optics ; Physics

Optics ; Physics, Applied ; Physics, Condensed Matter

WOS:000731182900001

WILEY-V C H VERLAG GMBH

20215111370419

Brain ; Electroencephalography ; Electrophysiology ; Neurons ; Photoacoustic effect

Biomedical Engineering:461.1 ; Medicine and Pharmacology:461.6 ; Biology:461.9 ; Light/Optics:741.1 ; Imaging Techniques:746 ; Acoustic Waves:751.1

Web of Science

Southern Univ Sci & Technol, Dept Biomed Engn, Shenzhen 518055, Guangdong, Peoples R China

Jin, Tian,Qi, Weizhi,Liang, Xiao,et al. Photoacoustic Imaging of Brain Functions: Wide Filed-of-View Functional Imaging with High Spatiotemporal Resolution[J]. Laser & Photonics Reviews,2021,16.

Jin, Tian,Qi, Weizhi,Liang, Xiao,Guo, Heng,Liu, Quanying,&Xi, Lei.(2021).Photoacoustic Imaging of Brain Functions: Wide Filed-of-View Functional Imaging with High Spatiotemporal Resolution.Laser & Photonics Reviews,16.

Jin, Tian,et al."Photoacoustic Imaging of Brain Functions: Wide Filed-of-View Functional Imaging with High Spatiotemporal Resolution".Laser & Photonics Reviews 16(2021).