南方科技大学知识苑(SUSTech KC): Sirtuin 7 Regulates Nitric Oxide Production and Apoptosis to Promote Mycobacterial Clearance in Macrophages

题名	Sirtuin 7 Regulates Nitric Oxide Production and Apoptosis to Promote Mycobacterial Clearance in Macrophages
作者	Zhang, Su 1; Liu, Yaya 2; Zhou, Xuefeng 3; Ou, Min 1; Xiao, Guohui 1; Li, Fang1 ; Wang, Zhongyuan 1; Wang, Zhaoqin 1; Liu, Lei1 ; Zhang, Guoliang 1
通讯作者	Zhang, Guoliang
发表日期	2021-12-03
DOI	10.3389/fimmu.2021.779235
发表期刊	Frontiers in Immunology 影响因子和分区
ISSN	1664-3224
卷号	12
摘要	The host immune system plays a pivotal role in the containment of Mycobacterium tuberculosis (Mtb) infection, and host-directed therapy (HDT) is emerging as an effective strategy to treat tuberculosis (TB), especially drug-resistant TB. Previous studies revealed that expression of sirtuin 7 (SIRT7), a nicotinamide adenine dinucleotide (NAD(+))-dependent deacetylase, was downregulated in macrophages after Mycobacterial infection. Inhibition of SIRT7 with the pan-sirtuin family inhibitor nicotinamide (NAM), or by silencing SIRT7 expression, promoted intracellular growth of Mtb and restricted the generation of nitric oxide (NO). Addition of the exogenous NO donor SNAP abrogated the increased bacterial burden in NAM-treated or SIRT7-silenced macrophages. Furthermore, SIRT7-silenced macrophages displayed a lower frequency of early apoptotic cells after Mycobacterial infection, and this could be reversed by providing exogenous NO. Overall, this study clarified a SIRT7-mediated protective mechanism against Mycobacterial infection through regulation of NO production and apoptosis. SIRT7 therefore has potential to be exploited as a novel effective target for HDT of TB.
关键词	Mycobacterium tuberculosis SIRT7 nitric oxide apoptosis macrophages
相关链接	[来源记录]
收录类别	SCI
语种	英语
学校署名	第一 ; 通讯
资助项目	National Natural Science Foundation of China[82170009,81873958,82100013] ; National Key Research and Development Plan[2020YFA0907200] ; Guangdong Scientific and Technological Foundation["2019B1515120041","2020B1111170014","2019A1515110055"] ; Shenzhen Scientific and Technological Foundation["KCXFZ202002011007083","JCYJ20180228162511084","JCYJ20190809104205706"] ; Sanming Project of Medicine in Shenzhen[SZSM201911009]
WOS研究方向	Immunology
WOS类目	Immunology
WOS记录号	WOS:000731016400001
出版者	FRONTIERS MEDIA SA
来源库	Web of Science
引用统计	被引频次[WOS]：12
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/259270
专题	南方科技大学第二附属医院南方科技大学第一附属医院
作者单位	1.Southern Univ Sci & Technol, Shenzhen Peoples Hosp 3, Natl Clin Res Ctr Infect Dis, Shenzhen, Peoples R China 2.Univ Hong Kong, Shenzhen Hosp, Dept Clin Oncol, Shenzhen, Peoples R China 3.Guangdong Med Univ, Sch Med Technol, Dongguan, Peoples R China
第一作者单位	南方科技大学第二附属医院; 南方科技大学第一附属医院
通讯作者单位	南方科技大学第二附属医院; 南方科技大学第一附属医院
第一作者的第一单位	南方科技大学第二附属医院; 南方科技大学第一附属医院
推荐引用方式 GB/T 7714	Zhang, Su,Liu, Yaya,Zhou, Xuefeng,et al. Sirtuin 7 Regulates Nitric Oxide Production and Apoptosis to Promote Mycobacterial Clearance in Macrophages[J]. Frontiers in Immunology,2021,12.
APA	Zhang, Su.,Liu, Yaya.,Zhou, Xuefeng.,Ou, Min.,Xiao, Guohui.,...&Zhang, Guoliang.(2021).Sirtuin 7 Regulates Nitric Oxide Production and Apoptosis to Promote Mycobacterial Clearance in Macrophages.Frontiers in Immunology,12.
MLA	Zhang, Su,et al."Sirtuin 7 Regulates Nitric Oxide Production and Apoptosis to Promote Mycobacterial Clearance in Macrophages".Frontiers in Immunology 12(2021).