NLRs guard metabolism to coordinate pattern- and effector-triggered immunity

Zhai, Keran1; Liang, Di1,2; Li, Helin1,3; Jiao, Fangyuan1,4; Yan, Bingxiao1,2; Liu, Jing1,2; Lei, Ziyao1,2; Huang, Li1,2; Gong, Xiangyu1,2; Wang, Xin1; Miao, Jiashun1; Wang, Yichuan5; Liu, Ji-Yun1; Zhang, Lin6; Wang, Ertao1; Deng, Yiwen1; Wen, Chi-Kuang1; Guo, Hongwei5; Han, Bin1; He, Zuhua1,4

2021-12-01

10.1038/s41586-021-04219-2

NATURE   影响因子和分区

0028-0836

1476-4687

Pattern-triggered immunity (PTI) and effector-triggered immunity (ETI) in plants enable them to respond to pathogens by activating the production of defence metabolites that orchestrate immune responses(1-4). How the production of defence metabolites is promoted by immune receptors and coordinated with broad-spectrum resistance remains elusive. Here we identify the deubiquitinase PICI1 as an immunity hub for PTI and ETI in rice (Oryza sativa). PICI1 deubiquitinates and stabilizes methionine synthetasesto activate methionine-mediated immunity principally through biosynthesis ofthe phytohormone ethylene. PICI1 istargeted for degradation by blast fungal effectors, including AvrPi9, to dampen PTI. Nucleotide-binding domain, leucine-rich-repeat-containing receptors (NLRB) in the plant immune system, such as PigmR, protect PICI1 from effector-mediated degradation to reboot the methionine-ethylene cascade. Natural variation in the PICI1 gene contributes to divergence in basal blast resistance between the rice subspecies indica andjaponica. Thus, NLRs govern an arms race with effectors, using a competitive mode that hinges on a critical defence metabolic pathway to synchronize PTI with ETI and ensure broad-spectrum resistance.

SCI

英语

NI论文 ; ESI高被引

其他

National Natural Science Foundation of China[32088102,31720103913,"U20A2021"] ; Chinese Academy of Sciences["XDB27040201","XDA24010304"] ; National Key Research and Development Program of China[2016YFD0100600] ; Science and Technology Commission of Shanghai Municipality[19391900300] ; Project of Special Funding for Crop Science Discipline Development of Yangzhou University[yzuxk202006] ; National Postdoctoral Program for Innovative Talents[BX20190346]

Science & Technology - Other Topics

Multidisciplinary Sciences

WOS:000730550300007

NATURE PORTFOLIO

BIOLOGY & BIOCHEMISTRY;CLINICAL MEDICINE;MULTIDISCIPLINARY;PLANT & ANIMAL SCIENCE;ENVIRONMENT/ECOLOGY;SOCIAL SCIENCES, GENERAL;MICROBIOLOGY;ECONOMICS BUSINESS;IMMUNOLOGY;MATERIALS SCIENCE;COMPUTER SCIENCE;SPACE SCIENCE;MOLECULAR BIOLOGY & GENETICS;CHEMISTRY;NEUROSCIENCE & BEHAVIOR;PHYSICS;GEOSCIENCES;ENGINEERING

Web of Science

1.Chinese Acad Sci, Inst Plant Physiol & Ecol, CAS Ctr Excellence Mol Plant Sci, Natl Key Lab Plant Mol Genet, Shanghai, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
3.Henan Univ, Sch Life Sci, Kaifeng, Peoples R China
4.Shanghai Tech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China
5.Southern Univ Sci & Technol, Inst Plant & Food Sci, Dept Biol, Shenzhen, Peoples R China
6.Yangzhou Univ, Jiangsu Key Lab Crop Genom & Mol Breeding, Yangzhou, Jiangsu, Peoples R China

Zhai, Keran,Liang, Di,Li, Helin,et al. NLRs guard metabolism to coordinate pattern- and effector-triggered immunity[J]. NATURE,2021.

Zhai, Keran.,Liang, Di.,Li, Helin.,Jiao, Fangyuan.,Yan, Bingxiao.,...&He, Zuhua.(2021).NLRs guard metabolism to coordinate pattern- and effector-triggered immunity.NATURE.

Zhai, Keran,et al."NLRs guard metabolism to coordinate pattern- and effector-triggered immunity".NATURE (2021).