南方科技大学知识苑(SUSTech KC): MultiMAP: dimensionality reduction and integration of multimodal data

题名	MultiMAP: dimensionality reduction and integration of multimodal data
作者	Jain，Mika Sarkin 1,2; Polanski，Krzysztof 2; Conde，Cecilia Dominguez 2; Chen，Xi2,3 ; Park，Jongeun 2,4; Mamanova，Lira 2; Knights，Andrew 2; Botting，Rachel A.5; Stephenson，Emily 5; Haniffa，Muzlifah 2,5; Lamacraft，Austen 1; Efremova，Mirjana 2,6; Teichmann，Sarah A.1,2
通讯作者	Jain，Mika Sarkin; Efremova，Mirjana; Teichmann，Sarah A.
发表日期	2021-12-01
DOI	10.1186/s13059-021-02565-y
发表期刊	Genome Biology 影响因子和分区
ISSN	1474-7596
EISSN	1474-760X
卷号	22 期号:1
摘要	Multimodal data is rapidly growing in many fields of science and engineering, including single-cell biology. We introduce MultiMAP, a novel algorithm for dimensionality reduction and integration. MultiMAP can integrate any number of datasets, leverages features not present in all datasets, is not restricted to a linear mapping, allows the user to specify the influence of each dataset, and is extremely scalable to large datasets. We apply MultiMAP to single-cell transcriptomics, chromatin accessibility, methylation, and spatial data and show that it outperforms current approaches. On a new thymus dataset, we use MultiMAP to integrate cells along a temporal trajectory. This enables quantitative comparison of transcription factor expression and binding site accessibility over the course of T cell differentiation, revealing patterns of expression versus binding site opening kinetics.
相关链接	[Scopus记录]
语种	英语
学校署名	其他
ESI学科分类	MOLECULAR BIOLOGY & GENETICS
Scopus记录号	2-s2.0-85121423774
来源库	Scopus
引用统计	被引频次[WOS]：32
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/259306
专题	南方科技大学生命科学学院_生物系
作者单位	1.Theory of Condensed Matter,Dept Physics,Cavendish Laboratory,University of Cambridge,Cambridge,JJ Thomson Ave,CB3 0HE,United Kingdom 2.Wellcome Sanger Institute,Wellcome Genome Campus,Cambridge,Hinxton,CB10 1SA,United Kingdom 3.Southern University of Science and Technology,Shenzhen,1088 Xueyuan Ave, Nanshan,518055,China 4.KAIST,Daejeon,291 Daehak-ro, Eoeun-dong, Yuseong-gu,South Korea 5.Biosciences Institute,Newcastle University,Newcastle upon Tyne,NE2 4HH,United Kingdom 6.Barts Cancer Institute,Queen Mary University of London,London,United Kingdom
推荐引用方式 GB/T 7714	Jain，Mika Sarkin,Polanski，Krzysztof,Conde，Cecilia Dominguez,et al. MultiMAP: dimensionality reduction and integration of multimodal data[J]. Genome Biology,2021,22(1).
APA	Jain，Mika Sarkin.,Polanski，Krzysztof.,Conde，Cecilia Dominguez.,Chen，Xi.,Park，Jongeun.,...&Teichmann，Sarah A..(2021).MultiMAP: dimensionality reduction and integration of multimodal data.Genome Biology,22(1).
MLA	Jain，Mika Sarkin,et al."MultiMAP: dimensionality reduction and integration of multimodal data".Genome Biology 22.1(2021).