Natural vs. Synthetic phosphate as efficient heterogeneous compounds for synthesis of quinoxalines

Amini，Abbas1,2; Fallah，Azadeh3; Sedaghat，Ahmad2; Gholami，Ahmad4,5; Cheng，Chun6; Gupta，Anju R.7

2021-12-01

10.3390/ijms222413665

International Journal of Molecular Sciences   影响因子和分区

1661-6596

1422-0067

Natural phosphate (NP) and synthetic fluorapatite phosphate (SFAP) were proposed as stable, inexpensive, readily available and recyclable catalysts for the condensation of 1,2‐diamines with 1,2‐dicarbonyls in methanol to afford quinoxaline at room temperature. NP provided as high as 92–99% yield for quinoxalines in short reaction times (i.e., 1–45 min), while SFAP created quinoxalines with 87–97% yield in 60–120 min. From the chemical analyses, X‐ray fluoresecency, X‐ray diffraction, energy dispersive X‐ray and Fourier‐transform infrared spectroscopy methods, two main phases (CaO, P2O5) appeared in NP together with other low content phases (SiO2, Fe2O3). Compared to other phases, apatite (CaO and P2O5 as Ca10(PO4)6) played a major role in the catalytic activity of NP. SFAP with similar Ca/P atomic ratio showed a relatively lower catalytic activity than NP for the condensation of 1,2‐diamine with 1,2‐dicarbonyl in methanol at ambient temperature. To investigate the recyclability of catalysts, the surface properties of NP and 6‐recycled NP were investigated using scanning electron microscopy, energy dispersive X‐ray and Brunauer–Emmett– Teller and Barrett–Joyner–Halenda methods. Some differences were observed in NP and 6‐recycled NP’s particle size, surface area, the volume and size of pores, and the content of elements; nevertheless, the use–reuse process did not noticeably change the catalytic property of NP.

Apatite Fluorapatite Heterogeneous catalyst Nano‐bio‐chemistry Natural phosphate Quinoxalines

英语

其他

CHEMISTRY

2-s2.0-85121372503

Scopus

1.Centre for Infrastructure of Engineering,Western Sydney University,Penrith,Bld Z, Locked Bag 1797, Kingswood Campus,2751,Australia
2.Department Mechanical Engineering,Australian College of Kuwait,Mishref, Safat,13015,Kuwait
3.Department of Chemistry,Payame Noor University,Tehran,Iran
4.Pharmaceutical Sciences Research Center,Shiraz University of Medical Sciences,Shiraz,Iran
5.Department of Pharmaceutical Biotechnology,School of Pharmacy,Shiraz University of Medical Sciences,Shiraz,Iran
6.Department of Materials Science and Engineering,Southern University of Science and Technology (SUSTech),Shenzhen,518055,China
7.Department of Mechanical Engineering,Industrial and Manufacturing Engineering,The University of Toledo,Toledo,43606,United States

Amini，Abbas,Fallah，Azadeh,Sedaghat，Ahmad,et al. Natural vs. Synthetic phosphate as efficient heterogeneous compounds for synthesis of quinoxalines[J]. International Journal of Molecular Sciences,2021,22(24).

Amini，Abbas,Fallah，Azadeh,Sedaghat，Ahmad,Gholami，Ahmad,Cheng，Chun,&Gupta，Anju R..(2021).Natural vs. Synthetic phosphate as efficient heterogeneous compounds for synthesis of quinoxalines.International Journal of Molecular Sciences,22(24).

Amini，Abbas,et al."Natural vs. Synthetic phosphate as efficient heterogeneous compounds for synthesis of quinoxalines".International Journal of Molecular Sciences 22.24(2021).