From primordial germ cells to spermatids in Caenorhabditis elegans

Wang，Xiangchuan3; Hu，Boyi3,4; Zhao，Zhongying4; Tse，Yu Chung1,2

2022-07-01

10.1016/j.semcdb.2021.12.005

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY   影响因子和分区

1084-9521

1096-3634

Development of a syncytial germline for gamete formation requires complex regulation of cytokinesis and cytoplasmic remodeling. Recently, several uncovered cellular events have been investigated in the Caenorhabditis elegans (C. elegans) germline. In these cellular processes, the factors involved in contractility are highly conserved with those of mitosis and meiosis. However, the underlying regulatory mechanisms are far more complicated than previously thought, likely due to the single syncytial germline structure. In this review, we highlight how the proteins involved in contractility ensure faithful cell division in different cellular contexts and how they contribute to maintaining intercellular bridge stability. In addition, we discuss the current understanding of the cellular events of cytokinesis and cytoplasmic remodeling during the development of the C. elegans germline, including progenitor germ cells, germ cells, and spermatocytes. Comparisons are made with relevant systems in Drosophila melanogaster (D. melanogaster) and other animal models.

Cytokinesis Cytoplasmic remodeling Germline Primordial germ cells Spermatogenesis

SCI

英语

第一 ; 通讯

National Natural Science Foundation of China[31671409] ; Natural Science Foundation of Guangdong Province of China[2020A1515010742]

Cell Biology ; Developmental Biology

Cell Biology ; Developmental Biology

WOS:000816882000013

ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD

MOLECULAR BIOLOGY & GENETICS

2-s2.0-85121360158

Web of Science

1.Core Research Facilities,Southern University of Science and Technology,Shenzhen,518055,China
2.Guangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research,Southern University of Science and Technology,Shenzhen,518055,China
3.School of Life Sciences,Department of Biology,Southern University of Science and Technology,Shenzhen,518055,China
4.Department of Biology,State Key Laboratory of Environmental and Biological Analysis,Hong Kong Baptist University,999077,Hong Kong

Wang，Xiangchuan,Hu，Boyi,Zhao，Zhongying,et al. From primordial germ cells to spermatids in Caenorhabditis elegans[J]. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY,2022,127.

Wang，Xiangchuan,Hu，Boyi,Zhao，Zhongying,&Tse，Yu Chung.(2022).From primordial germ cells to spermatids in Caenorhabditis elegans.SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY,127.

Wang，Xiangchuan,et al."From primordial germ cells to spermatids in Caenorhabditis elegans".SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY 127(2022).