Facile and Controllable Synthesis of the Renal-Clearable "Luminous Pearls" for in Vivo Afterglow/Magnetic Resonance Imaging

Wang, Jun1; Li, Qizhen1; Zhao, Hui2; Yue, Wentong1; Zhang, Kaiwen1; Jiang, Xingyu1; Li, Kai1

2022-01-25

10.1021/acsnano.1c07243

ACS NANO   影响因子和分区

1936-0851

1936-086X

To date, the strategic exploration of a synthetic approach to afford persistent luminescent nanoparticles (PLNPs) integrated with precisely controlled size/monodispersity and renal-clearable capability remains extremely challenging. Herein, we report a facile synthetic process with an elucidated mechanism to fine-tune the size for acquiring renal-clearable PLNPs, using mesoporous silica nanoparticles (MSNs) as a template. This strategy relies on the controlled crystallization of the precursor ions in the pore channels of MSNs at a high temperature, leading to the formation of monodispersed PLNPs with an average diameter as small as 2.5 nm after complete removal of MSN templates. The as-prepared ultrasmall PLNPs coated with polyethylene glycol exhibit uniform size, excellent water-dispersibility, good persistent luminescence, and high T-1 relaxivity (17.6 mM(-1) center dot S-1), ensuring their suitability for afterglow/magnetic resonance dual-modality imaging and subsequent in vivo renal clearance. Thus, our study provides a strategy to inspire the controlled synthesis of diverse PLNPs by using MSN templates, simultaneously addressing the critical issues of precise adjustment of size and body clearance for versatile biomedical applications.

mesoporous silica nanoparticles ultrasmall persistent luminescent nanoparticles size-tunable afterglow/magnetic resonance imaging renal clearance

SCI ; EI

英语

NI论文

第一 ; 共同第一 ; 通讯

Ministry of Science and Technology of China[2020YFA0908900] ; National Natural Science Foundation of China["U21A2097","31870991","81730051","21761142006"] ; Department of Science and Technology of Guangdong Province["2019ZT08Y191","2019QN01Y640"] ; Shenzhen Key Laboratory of Smart Healthcare Engineering[ZDSYS20200811144003009] ; Shenzhen Science and Technology Program["JCYJ20190809154011696","JCYJ20200109141222892","KQTD20190929172743294"]

Chemistry ; Science & Technology - Other Topics ; Materials Science

Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary

WOS:000734061400001

AMER CHEMICAL SOC

20220111410990

Luminescence ; Medical applications ; Silica nanoparticles

Light/Optics:741.1 ; Nanotechnology:761 ; Chemical Reactions:802.2

Web of Science

1.Southern Univ Sci & Technol, Dept Biomed Engn, Shenzhen Key Lab Smart Healthcare Engn, Shenzhen 518055, Peoples R China
2.Harbin Med Univ, Affiliated Hosp 2, Dept MRI Diag, Harbin 150086, Heilongjiang, Peoples R China

Wang, Jun,Li, Qizhen,Zhao, Hui,et al. Facile and Controllable Synthesis of the Renal-Clearable "Luminous Pearls" for in Vivo Afterglow/Magnetic Resonance Imaging[J]. ACS NANO,2022,16(1):462-472.

Wang, Jun.,Li, Qizhen.,Zhao, Hui.,Yue, Wentong.,Zhang, Kaiwen.,...&Li, Kai.(2022).Facile and Controllable Synthesis of the Renal-Clearable "Luminous Pearls" for in Vivo Afterglow/Magnetic Resonance Imaging.ACS NANO,16(1),462-472.

Wang, Jun,et al."Facile and Controllable Synthesis of the Renal-Clearable "Luminous Pearls" for in Vivo Afterglow/Magnetic Resonance Imaging".ACS NANO 16.1(2022):462-472.