Two dimensional nanosheets as immunoregulator improve HIV vaccine efficacy

Liu，Ye2; Balachandran，Yekkuni L.1; Li，Zulan3; Cong，Yulong3; Shao，Yiming4; Jiang，Xingyu1

2022-01-07

10.1039/d1sc04044h

Chemical Science   影响因子和分区

2041-6520

2041-6539

Two-dimensional (2D) nanosheets as carriers have shown promising potential for surface-displaying or loading various drugs. Nevertheless, developing sheet-like materials themselves into an immunoregulator has never been realized so far. In this study, we take advantage of the immunoregulatory effects of rare earth elements themselves and develop water-soluble erbium-dysprosium 2D nanosheets (2D NSs). Such 2D NSs can target lymph nodes and activate macrophages to improve vaccine efficacy in mice significantly. Transcriptome analysis further reveals that six critical molecules (Msr1, Ccr2, Serpinb9, Klrk1, Klrd1, Klrc1) closely correlate with 2D NS-mediated immunoregulationin vivo. For the first time, the present work realizes a proof-of-concept for designing immunoregulatory 2D NSs and shows a promising potential of 2D NSs for improving the immunoprophylaxis/immunotherapy of vaccines.

SCI ; EI

英语

NI论文

其他

WOS:000727603000001

20215311407448

Drug delivery ; Mammals ; Rare earths ; Vaccines

Medicine and Pharmacology:461.6 ; Nanotechnology:761 ; Inorganic Compounds:804.2 ; Solid State Physics:933

2-s2.0-85121866393

Scopus

1.Shenzhen Key Laboratory of Smart Healthcare Engineering,Department of Biomedical Engineering,Southern University of Science and Technology,Shenzhen,No. 1088 Xueyuan Rd, Nanshan District,518055,China
2.Institute of Medical Biology,Chinese Academy of Medical Sciences and Peking Union Medical College,Kunming,650000,China
3.Clinical Laboratory of South Building,Chinese P. L. A. General Hospital,Beijing,No. 28 Fuxing Road,100853,China
4.State Key Laboratory of Infectious Disease Prevention and Control,National Center for AIDS/STD Control and Prevention,Chinese Center for Disease Control and Prevention,Beijing,China

Liu，Ye,Balachandran，Yekkuni L.,Li，Zulan,et al. Two dimensional nanosheets as immunoregulator improve HIV vaccine efficacy[J]. Chemical Science,2022,13(1):178-187.

Liu，Ye,Balachandran，Yekkuni L.,Li，Zulan,Cong，Yulong,Shao，Yiming,&Jiang，Xingyu.(2022).Two dimensional nanosheets as immunoregulator improve HIV vaccine efficacy.Chemical Science,13(1),178-187.

Liu，Ye,et al."Two dimensional nanosheets as immunoregulator improve HIV vaccine efficacy".Chemical Science 13.1(2022):178-187.