| 题名 | A Novel Role for the Regulatory Nod-Like Receptor NLRP12 in Anti-Dengue Virus Response |
| 作者 | |
| 通讯作者 | Wu，Yongjian; Liu，Lei; Huang，Xi |
| 发表日期 | 2021-12-09
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| DOI | |
| 发表期刊 | |
| ISSN | 1664-3224
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| EISSN | 1664-3224
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| 卷号 | 12 |
| 摘要 | Dengue Virus (DENV) infection can cause severe illness such as highly fatality dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). Innate immune activation by Nod-like receptors (NLRs) is a critical part of host defense against viral infection. Here, we revealed a key mechanism of NLRP12-mediated regulation in DENV infection. Firstly, NLRP12 expression was inhibited in human macrophage following DENV or other flaviviruses (JEV, YFV, ZIKV) infection. Positive regulatory domain 1 (PRDM1) was induced by DENV or poly(I:C) and suppressed NLRP12 expression, which was dependent on TBK-1/IRF3 and NF-κB signaling pathways. Moreover, NLRP12 inhibited DENV and other flaviviruses (JEV, YFV, ZIKV) replication, which relied on the well-conserved nucleotide binding structures of its NACHT domain. Furthermore, NLRP12 could interact with heat shock protein 90 (HSP90) dependent on its Walker A and Walker B sites. In addition, NLRP12 enhanced the production of type I IFNs (IFN-α/β) and interferon-stimulated genes (ISGs), including IFITM3, TRAIL and Viperin. Inhibition of HSP90 with 17-DMAG impaired the upregulation of type I IFNs and ISGs induced by NLRP12. Taken together, we demonstrated a novel mechanism that NLRP12 exerted anti-viral properties in DENV and other flaviviruses (JEV, YFV, ZIKV) infection, which brings up a potential target for the treatment of DENV infection. |
| 关键词 | |
| 相关链接 | [Scopus记录] |
| 收录类别 | |
| 语种 | 英语
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| 学校署名 | 通讯
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| WOS研究方向 | Immunology
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| WOS类目 | Immunology
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| WOS记录号 | WOS:000744031700001
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| 出版者 | |
| Scopus记录号 | 2-s2.0-85121613226
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| 来源库 | Scopus
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| 引用统计 |
被引频次[WOS]：11
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| 成果类型 | 期刊论文 |
| 条目标识符 | http://sustech.caswiz.com/handle/2SGJ60CL/259970 |
| 专题 | 南方科技大学第二附属医院 |
| 作者单位 | 1.Center for Infection and Immunity and Guangdong Provincial Key Laboratory of Biomedical Imaging,The Fifth Affiliated Hospital of Sun Yat-sen University,Zhuhai,China 2.Zhongshan School of Medicine,Sun Yat-sen University,Guangzhou,China 3.Department of Clinical Laboratory,The Fifth Affiliated Hospital of Sun Yat-sen University,Zhuhai,China 4.Department of Pharmacy,The Fifth Affiliated Hospital,Sun Yat-sen University,Zhuhai,China 5.National Clinical Research Center for Infectious Diseases,Shenzhen Third People’s Hospital,Southern University of Science and Technology,Shenzhen,China |
| 通讯作者单位 | 南方科技大学第二附属医院 |
| 推荐引用方式 GB/T 7714 |
Li，Xingyu,Dong，Zhuo,Liu，Yan,et al. A Novel Role for the Regulatory Nod-Like Receptor NLRP12 in Anti-Dengue Virus Response[J]. Frontiers in Immunology,2021,12.
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| APA |
Li，Xingyu.,Dong，Zhuo.,Liu，Yan.,Song，Weifeng.,Pu，Jieying.,...&Huang，Xi.(2021).A Novel Role for the Regulatory Nod-Like Receptor NLRP12 in Anti-Dengue Virus Response.Frontiers in Immunology,12.
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| MLA |
Li，Xingyu,et al."A Novel Role for the Regulatory Nod-Like Receptor NLRP12 in Anti-Dengue Virus Response".Frontiers in Immunology 12(2021).
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| 条目包含的文件 | 条目无相关文件。 | |||||
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