Gold Nanoparticles Cure Bacterial Infection with Benefit to Intestinal Microflora

Li, Juanjuan1,2,3; Cha, Ruitao2,3; Zhao, Xiaohui2,3; Guo, Hongbo2,3; Luo, Huize1,2,3; Wang, Mingzheng1,2,3; Zhou, Fengshan1; Jiang, Xingyu2,3,4,5

2019-05

10.1021/acsnano.9b01002

ACS Nano   影响因子和分区

1936-0851

1936-086X

Antibiotics that are most used to cure bacterial infections in the clinic result in the imbalance of intestinal microflora, destroy the intestinal barrier, and induce bacterial resistance. There is an urgent need for antibacterial agent therapy for bacterial infections that does not destroy intestinal microflora. Herein, we applied 4,6-diamino-2-pyrimidinethiol (DAFT)-coated Au nanoparticles (D-Au NPs) for therapy of bacterial infection induced by Escherichia coli (E. coli) in the gut. We cultured D-Au NPs and E. coli in an anaerobic atmosphere to evaluate their bactericidal effect. We studied the microflora, distribution of Au, and biomarkers in mice after a 28-day oral administration to analyze the effect of Au NPs on mice. D-Au NPs cured bacterial infections more effectively than levofloxacin without harming intestinal microflora. D-Au NPs showed great potential as alternatives to oral antibiotics.

Au nanoparticles bacterial infections Escherichia coli intestinal microflora intestinal epithelial cells

SCI ; EI

英语

NI期刊

通讯

Special Fund for Independent Innovation and Industry Development in the Core Area in Haidian District of Beijing[255-kjc-020]

Chemistry ; Science & Technology - Other Topics ; Materials Science

Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary

WOS:000469886300013

AMER CHEMICAL SOC

20191506769682

Antibiotics ; Curing ; Escherichia coli ; Mammals ; Nanoparticles

Medicine and Pharmacology:461.6 ; Nanotechnology:761 ; Chemical Reactions:802.2 ; Solid State Physics:933

Web of Science

1.China Univ Geosci Beijing, Sch Mat Sci & Technol, Natl Lab Mineral Mat, Beijing Key Lab Mat Utilizat Nonmetall Minerals &, 29 Xueyuan Rd, Beijing 100083, Peoples R China
2.Natl Ctr NanoSci & Technol, CAS Ctr Excellence Nanosci, Beijing Engn Res Ctr BioNanotechnol, 11 Zhongguancun Beiyitiao, Beijing 100190, Peoples R China
3.Natl Ctr NanoSci & Technol, CAS Ctr Excellence Nanosci, CAS Key Lab Biomed Effects Nanomat & Nanosafety, 11 Zhongguancun Beiyitiao, Beijing 100190, Peoples R China
4.Southern Univ Sci & Technol, Dept Biomed Engn, 1088 Xueyuan Rd, Shenzhen 518055, Guangdong, Peoples R China
5.Univ Chinese Acad Sci, 19 A Yuquan Rd, Beijing 100049, Peoples R China

Li, Juanjuan,Cha, Ruitao,Zhao, Xiaohui,et al. Gold Nanoparticles Cure Bacterial Infection with Benefit to Intestinal Microflora[J]. ACS Nano,2019,13(5):5002-5014.

Li, Juanjuan.,Cha, Ruitao.,Zhao, Xiaohui.,Guo, Hongbo.,Luo, Huize.,...&Jiang, Xingyu.(2019).Gold Nanoparticles Cure Bacterial Infection with Benefit to Intestinal Microflora.ACS Nano,13(5),5002-5014.

Li, Juanjuan,et al."Gold Nanoparticles Cure Bacterial Infection with Benefit to Intestinal Microflora".ACS Nano 13.5(2019):5002-5014.