| 题名 | Interruption of Klf5 acetylation in basal progenitor cells promotes luminal commitment by activating Notch signaling |
| 作者 | |
| 通讯作者 | Zhang, Baotong; Dong, Jin-Tang |
| 发表日期 | 2021-12-21
|
| DOI | |
| 发表期刊 | |
| ISSN | 1673-8527
|
| EISSN | 1873-5533
|
| 卷号 | 49期号:6 |
| 摘要 | Prostate homeostasis and regeneration rely on the proper function of adult stem/progenitor cells (Ousset et al., 2012), which have also been considered as potential cells of origin for prostate cancer (Visvader, 2011), given their key positions in the lineage hierarchy and self-renewal capability. Accumulating evidence reveals the existence of multipotent progenitor cells in both basal and luminal
cells. For instance, CK5+ and p63+ basal cells can give rise to basal, luminal, and neuroendocrine cells
during postnatal prostate development, as indicated by lineage tracing assay (Ousset et al., 2012; Pignon et al., 2013; Lee et al., 2014). Lineage marked castration resistant Nkx3.1 expressing cells (CARNs), a rare luminal population, have shown self-renewal capability and bipotentiality during androgen driven regeneration (Wang et al., 2009). The balance between adult stem cell maintenance and differentiation is essential for maintaining homeostasis in prostate tissues, although the underlying molecular and cellular mechanisms are still poorly understood. |
| 相关链接 | [来源记录] |
| 收录类别 | |
| 语种 | 英语
|
| 学校署名 | 第一
; 通讯
|
| 资助项目 | Science, Technology and Innovation Commission of Shenzhen Municipality[JCYJ20200109141229255]
; National Cancer Institute, National Institutes of Health["R01CA171189","R01CA193455"]
; NIH/NCI[P30CA138292]
|
| WOS研究方向 | Biochemistry & Molecular Biology
; Genetics & Heredity
|
| WOS类目 | Biochemistry & Molecular Biology
; Genetics & Heredity
|
| WOS记录号 | WOS:000814089700007
|
| 出版者 | |
| 来源库 | 人工提交
|
| 引用统计 |
被引频次[WOS]：2
|
| 成果类型 | 期刊论文 |
| 条目标识符 | http://sustech.caswiz.com/handle/2SGJ60CL/260234 |
| 专题 | 南方科技大学医学院_人类细胞生物和遗传学系 南方科技大学医学院 |
| 作者单位 | 1.Department of Human Cell Biology and Genetics, Southern University of Science and Technology School of Medicine, Shenzhen, China 2.Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA 30322, USA 3.Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA |
| 第一作者单位 | 人类细胞生物和遗传学系; 南方科技大学医学院 |
| 通讯作者单位 | 人类细胞生物和遗传学系; 南方科技大学医学院 |
| 第一作者的第一单位 | 人类细胞生物和遗传学系; 南方科技大学医学院 |
| 推荐引用方式 GB/T 7714 |
Zhang, Baotong,Xia, Siyuan,Liu, Mingcheng,et al. Interruption of Klf5 acetylation in basal progenitor cells promotes luminal commitment by activating Notch signaling[J]. Journal of Genetics and Genomics,2021,49(6).
|
| APA |
Zhang, Baotong.,Xia, Siyuan.,Liu, Mingcheng.,Li, Xiawei.,Shuai, Shimin.,...&Dong, Jin-Tang.(2021).Interruption of Klf5 acetylation in basal progenitor cells promotes luminal commitment by activating Notch signaling.Journal of Genetics and Genomics,49(6).
|
| MLA |
Zhang, Baotong,et al."Interruption of Klf5 acetylation in basal progenitor cells promotes luminal commitment by activating Notch signaling".Journal of Genetics and Genomics 49.6(2021).
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| 条目包含的文件 | ||||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | 操作 | |
| Interruption of Klf5（4020KB） | -- | -- | 开放获取 | -- | 浏览 | |
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