Dehydrocurvularin is a potent antineoplastic agent irreversibly blocking ATP-citrate lyase: evidence from chemoproteomics

Deng, Zhangshuang1,2,3; Wong, Nai-Kei4; Guo, Zhiyong2; Zou, Kun2; Xiao, Youli5; Zhou, Yiqing1,5

2019-04-14

10.1039/c9cc00256a

CHEMICAL COMMUNICATIONS   影响因子和分区

1359-7345

1364-548X

Natural-product macrolide 10,11-dehydrocurvularin (DCV) was revealed to be a potent irreversible inhibitor of ATP-citrate lyase (ACLY) via classical chemoproteomic profiling, which mechanistically illuminates the anti-cancer mode of action of DCV and its analogues.

SCI ; EI

英语

NI期刊

其他

Chemistry

Chemistry, Multidisciplinary

WOS:000467970400009

ROYAL SOC CHEMISTRY

CHEMISTRY

Web of Science

1.Changshu Inst Technol, Sch Biotechnol & Food Engn, Changshu 215500, Jiangsu, Peoples R China
2.China Three Gorges Univ, Coll Biol & Pharmaceut Sci, Hubei Key Lab Nat Prod Res & Dev, Yichang 443002, Peoples R China
3.China Three Gorges Univ, Key Lab Three Gorges Reg Plant Genet & Germplasm, Yichang 443002, Peoples R China
4.Southern Univ Sci & Technol, Hosp 2, Shenzhen Peoples Hosp 3, Dept Infect Dis, Shenzhen 518112, Peoples R China
5.Chinese Acad Sci, CAS Ctr Excellence Mol Plant Sci, Inst Plant Physiol & Ecol, Shanghai 200032, Peoples R China

Deng, Zhangshuang,Wong, Nai-Kei,Guo, Zhiyong,et al. Dehydrocurvularin is a potent antineoplastic agent irreversibly blocking ATP-citrate lyase: evidence from chemoproteomics[J]. CHEMICAL COMMUNICATIONS,2019,55(29):4194-4197.

Deng, Zhangshuang,Wong, Nai-Kei,Guo, Zhiyong,Zou, Kun,Xiao, Youli,&Zhou, Yiqing.(2019).Dehydrocurvularin is a potent antineoplastic agent irreversibly blocking ATP-citrate lyase: evidence from chemoproteomics.CHEMICAL COMMUNICATIONS,55(29),4194-4197.

Deng, Zhangshuang,et al."Dehydrocurvularin is a potent antineoplastic agent irreversibly blocking ATP-citrate lyase: evidence from chemoproteomics".CHEMICAL COMMUNICATIONS 55.29(2019):4194-4197.