Directed self-assembly of herbal small molecules into sustained release hydrogels for treating neural inflammation

Zheng, Jun1; Fan, Rong2; Wu, Huiqiong1,3; Yao, Honghui4; Yan, Yujie4; Liu, Jiamiao4; Ran, Lu5; Sun, Zhifang1; Yi, Lunzhao5; Dang, Li6,7; Gan, Pingping8; Zheng, Piao9; Yang, Tilong10; Zhang, Yi1,2; Tang, Tao2; Wang, Yang2

2019-04-08

10.1038/s41467-019-09601-3

Nature Communications   影响因子和分区

2041-1723

Self-assembling natural drug hydrogels formed without structural modification and able to act as carriers are of interest for biomedical applications. A lack of knowledge about natural drug gels limits there current application. Here, we report on rhein, a herbal natural product, which is directly self-assembled into hydrogels through noncovalent interactions. This hydrogel shows excellent stability, sustained release and reversible stimuli-responses. The hydrogel consists of a three-dimensional nanofiber network that prevents premature degradation. Moreover, it easily enters cells and binds to toll-like receptor 4. This enables rhein hydrogels to significantly dephosphorylate I kappa B alpha, inhibiting the nuclear translocation of p65 at the NF kappa B signalling pathway in lipopolysaccharide-induced BV2 microglia. Subsequently, rhein hydrogels alleviate neuroinflammation with a long-lasting effect and little cytotoxicity compared to the equivalent free-drug in vitro. This study highlights a direct self-assembly hydrogel from natural small molecule as a promising neuroinflammatory therapy.

SCI

英语

ESI高被引 ; NI论文

其他

Hunan Provincial Natural Science Foundation of China[2019JJ50960]

Science & Technology - Other Topics

Multidisciplinary Sciences

WOS:000463695400019

NATURE PUBLISHING GROUP

Web of Science

1.Cent S Univ, Coll Chem & Chem Engn, Key Lab Hunan Prov Water Environm & Agr Prod Safe, Changsha 410083, Hunan, Peoples R China
2.Cent S Univ, Xiangya Hosp, Inst Integrat Med, Key Lab Hunan Prov Liver Manifestat Tradit Chines, Changsha 410008, Hunan, Peoples R China
3.Zhengzhou Univ, Minist Educ, Key Laboratry Mat Proc & Mold, Zhengzhou 450002, Henan, Peoples R China
4.Cent S Univ, Xiangya Sch Med, Changsha 410013, Hunan, Peoples R China
5.Kunming Univ Sci & Technol, Yunnan Food Safety Res Inst, Kunming 650500, Yunnan, Peoples R China
6.Shantou Univ, Dept Chem, Shantou 515063, Peoples R China
7.Shantou Univ, Key Lab Preparat & Applicat Ordered Struct Mat Gu, Shantou 515063, Peoples R China
8.Cent S Univ, Xiangya Hosp, Dept Oncol, Changsha 410008, Hunan, Peoples R China
9.Hunan Univ Chinese Med, Coll Integrated Tradit Chinese & Western Med, Changsha 410208, Hunan, Peoples R China
10.Southern Univ Sci & Technol, Shenzhen 518055, Peoples R China

Zheng, Jun,Fan, Rong,Wu, Huiqiong,et al. Directed self-assembly of herbal small molecules into sustained release hydrogels for treating neural inflammation[J]. Nature Communications,2019,10.

Zheng, Jun.,Fan, Rong.,Wu, Huiqiong.,Yao, Honghui.,Yan, Yujie.,...&Wang, Yang.(2019).Directed self-assembly of herbal small molecules into sustained release hydrogels for treating neural inflammation.Nature Communications,10.

Zheng, Jun,et al."Directed self-assembly of herbal small molecules into sustained release hydrogels for treating neural inflammation".Nature Communications 10(2019).