Formation of dioxins from triclosan with active chlorine: A potential risk assessment

Wu, Jian-lin1,2; Ji, Fenfen1; Zhang, Hongna1; Hu, Chuanqin3; Wong, Ming Hung4,5,6; Hu, Di1; Cai, Zongwei1

2019-04-05

10.1016/j.jhazmat.2018.12.088

JOURNAL OF HAZARDOUS MATERIALS   影响因子和分区

0304-3894

1873-3336

Tridosan, a widely used antimicrobial agent, can increase colitis-associated colon tumorigenesis, and induce liver fibrosis and cancer in mice through mechanisms which may be relevant in humans. In this study, an analytical method using gas chromatography-mass spectrometry (GC-MS) and high resolution gas chromatography-high resolution mass spectrometry (HRGC-HRMS) was developed to measure dioxins and chlorinated derivatives from triclosan in the presence of active chlorine in seawater matrix. Formation yields of dioxins and chlorinated triclosans were assessed at different initial precursor concentrations under dark and UV light irradiation conditions. Results showed that triclosan was rapidly transformed to its chlorinated derivatives, i.e. tetraclosans and pentaclosans, of which the formation yields peaked after 1 h of reaction. UV light was the key factor to promote the formation of dioxins. With the same initial triclosan/active chlorine ratio, the highest yield of dioxins was observed with lower initial concentrations of triclosan under UV irradiation. Five dioxins, including 2,8-DCDD, 1,208-TICDD, 2,3,7-TrCDD, 1,2,3,8-TeCDD, and 2,3,7,8-TeCDD, were identified and quantified. 2,3,7,8-TeCDD, the most toxic dioxin, was firstly reported as the photo transformation product of triclosan in aquatic solution. Results presented here are useful for a comprehensive understanding of the fate and toxicity of triclosan in contaminated waters.

Triclosan Dioxins Photo-transformation GC-MS HRGC-HRMS

SCI ; EI

英语

其他

Collaborative Research Fund of Hong Kong Research Grants Council[C2014-14E]

Engineering ; Environmental Sciences & Ecology

Engineering, Environmental ; Environmental Sciences

WOS:000459845000016

ELSEVIER SCIENCE BV

20185206312512

Antimicrobial agents ; Chlorine ; Diseases ; Gas chromatography ; Irradiation ; Mammals ; Mass spectrometry ; Risk assessment ; Water pollution

Water Pollution:453 ; Medicine and Pharmacology:461.6 ; Chemistry:801 ; Chemical Operations:802.3 ; Chemical Products Generally:804 ; Organic Compounds:804.1 ; Accidents and Accident Prevention:914.1

ENGINEERING

Web of Science

1.Hong Kong Baptist Univ, Dept Chem, State Key Lab Environm & Biol Anal, Kowloon Tong, Hong Kong, Peoples R China
2.Macau Univ Sci & Technol, State Key Lab Qual Res Chinese Med, Macau, Peoples R China
3.Beijing Technol & Business Univ, Beijing Lab Food Qual & Safety, Sch Food & Chem Engn, Beijing, Peoples R China
4.Southern Univ Sci & Technol, Guangdong Prov Key Lab Soil & Groundwater Pollut, Shenzhen, Peoples R China
5.Southern Univ Sci & Technol, State Environm Protect Key Lab Integrated Surface, Shenzhen, Peoples R China
6.Educ Univ Hong Kong, Consortium Hlth Environm Educ & Res, Tai Po, Hong Kong, Peoples R China

Wu, Jian-lin,Ji, Fenfen,Zhang, Hongna,et al. Formation of dioxins from triclosan with active chlorine: A potential risk assessment[J]. JOURNAL OF HAZARDOUS MATERIALS,2019,367:128-136.

Wu, Jian-lin.,Ji, Fenfen.,Zhang, Hongna.,Hu, Chuanqin.,Wong, Ming Hung.,...&Cai, Zongwei.(2019).Formation of dioxins from triclosan with active chlorine: A potential risk assessment.JOURNAL OF HAZARDOUS MATERIALS,367,128-136.

Wu, Jian-lin,et al."Formation of dioxins from triclosan with active chlorine: A potential risk assessment".JOURNAL OF HAZARDOUS MATERIALS 367(2019):128-136.