南方科技大学知识苑(SUSTech KC): Dual functions of STAT3 in LPS-induced angiogenesis of hepatocellular carcinoma

题名	Dual functions of STAT3 in LPS-induced angiogenesis of hepatocellular carcinoma
作者	Wang, Zhuo1,2,3,4 ; Yan, Ming 1,2 ; Li, Jia'an 1,2 ; Long, Jiafu 3,4; Li, Yan1,2 ; Zhang, Hongmin1,2
通讯作者	Wang, Zhuo; Li, Yan; Zhang, Hongmin
发表日期	2019-04
DOI	10.1016/j.bbamcr.2018.11.016
发表期刊	BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 影响因子和分区
ISSN	0167-4889
EISSN	1879-2596
卷号	1866 期号:4页码:566-574
摘要	Hepatocellular carcinoma (HCC) is a long-term consequence of chronic inflammatory liver injury. Hepatic injury is associated with a defective intestinal barrier and increased hepatic exposure to bacterial products including lipopolysaccharide (LPS), which promotes hepatocarcinogenesis. Despite its clinical significance, the molecular mediator linking chronic inflammation with HCC development remains to be clarified. In this study, we explored the significant dual functions of active signal transducer and activator of transcription 3 (STAT3) in LPS-induced angiogenesis of HCC. The in vitro effects of active STAT3 in tumor cells and endothelial cells were assessed using angiogenesis assay, ELISA, confocal assay, flow cytometry and western blot. The in vivo role of active STAT3 was assessed in xenografts model in nude mice. Here we report a novel mechanism by which LPS/STAT3 signaling promotes the angiogenesis of HCC both in vitro and in vivo. STAT3 activated by LPS increases the production of vascular endothelial growth factor (VEGF) by tumor cells, which not only promotes the proliferation of HCC cells but also stimulates the migration and tubulogenesis of endothelial cells through STAT3 activation and hence promotes angiogenesis in HCC. Our findings not only provide a potential mechanism by which bacterial infection enhances HCC oncogenesis through promoting the angiogenesis in liver, but also suggest that targeting STAT3 might be an effective therapeutic strategy in HCC treatment considering the dual roles of STAT3 in angiogenesis.
关键词	HCC LPS STAT3 VEGF Angiogenesis
相关链接	[来源记录]
收录类别	SCI
语种	英语
学校署名	第一 ; 通讯
资助项目	Natural Science Foundation of China[31670753] ; Natural Science Foundation of China[81702798]
WOS研究方向	Biochemistry & Molecular Biology ; Cell Biology
WOS类目	Biochemistry & Molecular Biology ; Cell Biology
WOS记录号	WOS:000460077700004
出版者	ELSEVIER SCIENCE BV
ESI学科分类	MOLECULAR BIOLOGY & GENETICS
来源库	Web of Science
引用统计	被引频次[WOS]：9
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/26152
专题	生命科学学院_生物系南方科技大学医学院
作者单位	1.Southern Univ Sci & Technol, Guangdong Prov Key Lab Cell Microenvironm & Dis R, Dept Biol, Shenzhen Key Lab Cell Microenvironm, Shenzhen 518055, Peoples R China 2.Southern Univ Sci & Technol, SUSTech HKU Joint Labs Matrix Biol & Dis, Shenzhen 518055, Peoples R China 3.Nankai Univ, State Key Lab Med Chem Biol, Tianjin 300071, Peoples R China 4.Nankai Univ, Coll Life Sci, Tianjin 300071, Peoples R China
第一作者单位	生物系; 南方科技大学医学院
通讯作者单位	生物系; 南方科技大学医学院
第一作者的第一单位	生物系; 南方科技大学医学院
推荐引用方式 GB/T 7714	Wang, Zhuo,Yan, Ming,Li, Jia'an,et al. Dual functions of STAT3 in LPS-induced angiogenesis of hepatocellular carcinoma[J]. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH,2019,1866(4):566-574.
APA	Wang, Zhuo,Yan, Ming,Li, Jia'an,Long, Jiafu,Li, Yan,&Zhang, Hongmin.(2019).Dual functions of STAT3 in LPS-induced angiogenesis of hepatocellular carcinoma.BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH,1866(4),566-574.
MLA	Wang, Zhuo,et al."Dual functions of STAT3 in LPS-induced angiogenesis of hepatocellular carcinoma".BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 1866.4(2019):566-574.