The interaction of chitosan and BMP-2 tuned by deacetylation degree and pH value

Wang, Qun1,2; Wang, Menghao1; Li, Pengfei3; Wang, Kefeng3; Fang, Liming4; Ren, Fuzeng5; Lu, Guoming6; Lu, Xiong1

2019-04

10.1002/jbm.a.36593

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A   影响因子和分区

1549-3296

1552-4965

Integrating proteins with chitosan (CS) can not only improve the biocompatibility of CS, but also enable the sustained release of proteins. The deacetylation degree (DD) and pH conditions are considered as the two most important factors affecting the interaction between CS and proteins. In this study, the effects of CS with different DDs and pH conditions on bone morphogenetic protein-2 (BMP-2) adsorption were evaluated using the molecular dynamics (MD) method. The results showed that the interaction energy first increased and then decreased, with the increase of the DD in the range of 0-100%; the strongest interaction was found between BMP-2 and 75% DD-CS surface. Furthermore, decreasing pH values favor the interaction between BMP-2 and CS surfaces. These results are useful to gain a better understanding of the interaction mechanism between polysaccharides and proteins and provide a meaningful reference for the application of CS with different DDs and pH conditions. (c) 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 107A: 769-779, 2019.

chitosan deacetylation degree pH bone morphogenetic Protein-2 molecular dynamics method

SCI ; EI

英语

其他

Education Department Program of Sichuan province[16ZB0313]

Engineering ; Materials Science

Engineering, Biomedical ; Materials Science, Biomaterials

WOS:000458824000006

WILEY

20185206299651

Acetylation ; Biocompatibility ; Bone ; Chitosan ; Molecular dynamics ; pH

Immunology:461.9.1 ; Chemistry, General:801.1 ; Physical Chemistry:801.4 ; Chemical Reactions:802.2 ; Organic Compounds:804.1

MATERIALS SCIENCE

Web of Science

1.Southwest Jiaotong Univ, Sch Mat Sci & Engn, Minist Educ, Key Lab Adv Technol Mat, Chengdu 610031, Sichuan, Peoples R China
2.MianYang Teachers Coll, Coll Life Sci & Biotechnol, Mianyang 621006, Sichuan, Peoples R China
3.Sichuan Univ, Genome Res Ctr Biomat, Natl Engn Res Ctr Biomat, Chengdu 610065, Sichuan, Peoples R China
4.South China Univ Technol, Sch Mat Sci & Engn, Dept Polymer Sci & Engn, Guangzhou 510641, Guangdong, Peoples R China
5.South Univ Sci & Technol China, Dept Mat Sci & Engn, Shenzhen 518055, Guangdong, Peoples R China
6.Univ Elect Sci & Technol China, Sch Comp Sci & Engn, Chengdu 610054, Sichuan, Peoples R China

Wang, Qun,Wang, Menghao,Li, Pengfei,et al. The interaction of chitosan and BMP-2 tuned by deacetylation degree and pH value[J]. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A,2019,107(4):769-779.

Wang, Qun.,Wang, Menghao.,Li, Pengfei.,Wang, Kefeng.,Fang, Liming.,...&Lu, Xiong.(2019).The interaction of chitosan and BMP-2 tuned by deacetylation degree and pH value.JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A,107(4),769-779.

Wang, Qun,et al."The interaction of chitosan and BMP-2 tuned by deacetylation degree and pH value".JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A 107.4(2019):769-779.