Mussel-inspired dopamine oligomer intercalated tough and resilient gelatin methacryloyl (GelMA) hydrogels for cartilage regeneration

Gan, Donglin1; Xu, Tong1; Xing, Wensi1; Wang, Menghao1; Fang, Ju2; Wang, Kefeng3; Ge, Xiang4; Chan, Chun Wai5; Ren, Fuzeng2; Tan, Hui6; Lu, Xiong1

2019-03-14

10.1039/c8tb01664j

Journal of Materials Chemistry B   影响因子和分区

2050-750X

2050-7518

Gelatin methacryloyl (GelMA) hydrogels are widely used for tissue regeneration. Nonetheless, a pure GelMA hydrogel cannot efficiently serve for cartilage regeneration because of weak mechanical properties and brittleness. In this study, we established a mussel-inspired strategy for tuning the mechanical properties of GelMA hydrogels by intercalating oligomers of dopamine methacrylate (ODMA) into the chain of GelMA. After the ODMA intercalated, the hydrogel became tough and resilient. This is because ODMA intercalation reduces the high density of entangled GelMA chains and introduces additional sacrificial physical cross-linking into the hydrogel. Rheological analysis showed that the ODMA-GelMA hydrogel was mechanically stable at body temperature. The hydrogel also manifested a sustained protein release because of the ODMA catechol groups. Furthermore, the ODMA-GelMA hydrogel was found to have good biocompatibility and affinity for cells and tissues because of the catechol groups on ODMA. In vitro, the hydrogel promoted mesenchymal stem cell adhesion and growth, and in vivo, it promoted cartilage regeneration after loading with chondroitin sulfate or TGF-(3). The hydrogel can serve as a growth-factor-free scaffold for cartilage regeneration. This hydrogel not only provided a favorable microenvironment for cartilage repair but also could serve as a promising candidate material for repair of other tissues. This mussel-inspired strategy of introduction of reactive oligomers instead of polymers into a brittle hydrogel network may be extended to the development of other tough hydrogels for biomedical applications.

SCI ; EI

英语

其他

Independent Innovation Fund of Tianjin University[2018XGP-0030]

Materials Science

Materials Science, Biomaterials

WOS:000463080800013

ROYAL SOC CHEMISTRY

20191106619592

Amines ; Biocompatibility ; Biomechanics ; Cartilage ; Cell adhesion ; Cell culture ; Fracture mechanics ; Functional polymers ; Histology ; Hydrogels ; Mechanical properties ; Medical applications ; Molluscs ; Neurophysiology ; Oligomers ; Phenols ; Repair ; Stem cells ; Sulfur compounds ; Tissue

Bioengineering and Biology:461 ; Marine Science and Oceanography:471 ; Chemical Products Generally:804 ; Organic Compounds:804.1 ; Polymeric Materials:815.1 ; Organic Polymers:815.1.1 ; Maintenance:913.5 ; Mechanics:931.1

Web of Science

1.Southwest Jiaotong Univ, Key Lab Adv Technol Mat, Minist Educ, Sch Mat Sci & Engn, Chengdu 610031, Sichuan, Peoples R China
2.South Univ Sci & Technol, Dept Mat Sci & Engn, Shenzhen 518055, Guangdong, Peoples R China
3.Sichuan Univ, Natl Engn Res Ctr Biomat, Chengdu 610064, Sichuan, Peoples R China
4.Tianjin Univ, Key Lab Mech Theory & Equipment Design, Sch Mech Engn, Minist Educ, Tianjin 300072, Peoples R China
5.Chinese Univ Hong Kong, Sch Chinese Med, Shatin, Hong Kong, Peoples R China
6.Shenzhen Univ, Shenzhen Key Lab Neurosurg, Affiliated Hosp 1, Shenzhen 518035, Guangdong, Peoples R China

Gan, Donglin,Xu, Tong,Xing, Wensi,et al. Mussel-inspired dopamine oligomer intercalated tough and resilient gelatin methacryloyl (GelMA) hydrogels for cartilage regeneration[J]. Journal of Materials Chemistry B,2019,7(10):1716-1725.

Gan, Donglin.,Xu, Tong.,Xing, Wensi.,Wang, Menghao.,Fang, Ju.,...&Lu, Xiong.(2019).Mussel-inspired dopamine oligomer intercalated tough and resilient gelatin methacryloyl (GelMA) hydrogels for cartilage regeneration.Journal of Materials Chemistry B,7(10),1716-1725.

Gan, Donglin,et al."Mussel-inspired dopamine oligomer intercalated tough and resilient gelatin methacryloyl (GelMA) hydrogels for cartilage regeneration".Journal of Materials Chemistry B 7.10(2019):1716-1725.