Versatile Strategy To Generate a Rhodamine Triplet State as Mitochondria-Targeting Visible-Light Photosensitizers for Efficient Photodynamic Therapy

Liu, Chuangjun1,3; Zhou, Lihua2; Wei, Fangfang1; Li, Ling1; Zhao, Shunan1; Gong, Ping2; Cai, Lintao2; Wong, Keith Man-Chung1

2019-03-06

10.1021/acsami.8b20224

ACS Applied Materials & Interfaces   影响因子和分区

1944-8244

1944-8252

Through the use of a rhodamine-appended chelate, bpy-Rho, a versatile strategy has been demonstrated to readily form mitochondria-targeting photosensitizers via the incorporation of a variety of luminescent transition-metal systems, M-Rho, such as Re(I), Ir(III), Pt(II), and Rh(III). The emission from the rhodamine singlet excited state and the transition-metal triplet excited state is partially quenched by the depopulation of them into the dark rhodamine triplet excited state. The generation of the triplet excited state of a rhodamine moiety endows the complexes with mitochondria-targeting photosensitizing ability to form singlet oxygen (O-1(2)) for use as a photodynamic therapy (PDT) agent upon visible-light irradiation. The combination of the rhodamine organic dye and luminescent transition-metal centers in such hybrid systems exhibits the synergistic merits for the biological applications, including low dark cytotoxicity, selective tumor cell uptake, high molar absorptivity suitable for low-energy excitation in the visible region, and high photostability. The corresponding in vitro photocytotoxicity and in vivo photo-antitumor efficacy have also been studied to demonstrate the potential PDT application of M-Rho.

luminescent transition metal complex photosensitizer photodynamic therapy triplet state rhodamine

SCI ; EI

英语

第一 ; 通讯

Shenzhen Technology and Innovation Committee[JCYJ20170307110203786] ; Shenzhen Technology and Innovation Committee[JCYJ20170817110721105]

Science & Technology - Other Topics ; Materials Science

Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary

WOS:000460996900013

AMER CHEMICAL SOC

20191006592110

Hybrid systems ; Iridium compounds ; Light ; Luminescence ; Metal complexes ; Mitochondria ; Photodynamic therapy ; Photosensitizers ; Platinum compounds ; Rhenium compounds ; Rhodium compounds ; Transition metals

Biological Materials and Tissue Engineering:461.2 ; Medicine and Pharmacology:461.6 ; Metallurgy and Metallography:531 ; Light/Optics:741.1 ; Inorganic Compounds:804.2 ; Mathematics:921 ; Atomic and Molecular Physics:931.3

Web of Science

1.Southern Univ Sci & Technol, Dept Chem, 1088 Xueyuan Blvd, Shenzhen 518055, Peoples R China
2.Chinese Acad Sci, Shenzhen Inst Adv Technol,Shenzhen Engn Lab Nanom, CAS Key Lab Hlth Informat CAS HK Joint Lab Biomat, Inst Biomed & Biotechnol,Guangdong Key Lab Nanome, Shenzhen 518055, Peoples R China
3.Huanghuai Univ, Coll Chem & Pharmaceut Engn, Zhumadian 463000, Peoples R China

Liu, Chuangjun,Zhou, Lihua,Wei, Fangfang,et al. Versatile Strategy To Generate a Rhodamine Triplet State as Mitochondria-Targeting Visible-Light Photosensitizers for Efficient Photodynamic Therapy[J]. ACS Applied Materials & Interfaces,2019,11(9):8797-8806.

Liu, Chuangjun.,Zhou, Lihua.,Wei, Fangfang.,Li, Ling.,Zhao, Shunan.,...&Wong, Keith Man-Chung.(2019).Versatile Strategy To Generate a Rhodamine Triplet State as Mitochondria-Targeting Visible-Light Photosensitizers for Efficient Photodynamic Therapy.ACS Applied Materials & Interfaces,11(9),8797-8806.

Liu, Chuangjun,et al."Versatile Strategy To Generate a Rhodamine Triplet State as Mitochondria-Targeting Visible-Light Photosensitizers for Efficient Photodynamic Therapy".ACS Applied Materials & Interfaces 11.9(2019):8797-8806.