Association of prenatal exposure to organochlorine pesticides and birth size

Fang, Jing1; Liu, Hongxiu2,3,4; Zhao, Hongzhi1; Wong, Minghung5,6,7; Xu, Shunqing2,3,4; Cai, Zongwei1

2019-03

10.1016/j.scitotenv.2018.10.384

SCIENCE OF THE TOTAL ENVIRONMENT   影响因子和分区

0048-9697

1879-1026

There has been substantial evidence showing the adverse effects of organochlorine pesticide (OCP) exposure on human, but studies focused on the prenatal exposure effects at low OCP levels on infant birth size were scarce and controversial. In this study, cord serum samples were collected at the delivery from 1028 pairs of mothers and newborns in Wuhan, China and investigated the associations of prenatal exposure to OCPs and birth size. The prenatal exposure of hexachlorocyclohexane isomers (HCHs), p,p'-dichlorodiphenyltrichloroethane (p,p'-DDT) and its metabolites were analyzed. The associations between birth size and prenatal OCP exposure were examined by multiple linear regressions. A sex-specific relationship between the OCP exposure and birth size was observed. beta-HCH was negatively associated with birth weight and ponderal index for boys [adjusted beta = -28.61; 95% confidence interval (CI): - 54.84, -4.37 and adjusted beta = -0.17; 95% CI: -032, -0.01, respectively], whilst no significant associations with prenatal exposure of OCPs were found among girls. The inverse association of prenatal exposure to low levels of beta-HCH was shown sex-specific difference, which was only observed significantly in boys. The findings strengthened the evidence that the fetal development was influenced by prenatal exposure to certain OCPs and the effects might be different in the newborn sex. (C) 2018 Published by Elsevier B.V.

Organochlorines pesticides Cord serum Birth size

SCI ; EI

英语

其他

Research Grants Council (RGC) of Hong Kong, China[GRF 12304117] ; Research Grants Council (RGC) of Hong Kong, China[C2014-14E]

Environmental Sciences & Ecology

Environmental Sciences

WOS:000458630100058

ELSEVIER SCIENCE BV

20184706106635

Body fluids ; Isomers

Biological Materials and Tissue Engineering:461.2 ; Chemical Agents and Basic Industrial Chemicals:803 ; Chemical Products Generally:804

ENVIRONMENT/ECOLOGY

Web of Science

1.Hong Kong Baptist Univ, Dept Chem, State Key Lab Environm & Biol Anal, Hong Kong, Peoples R China
2.Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Key Lab Environm & Hlth,Minist Educ, Wuhan, Hubei, Peoples R China
3.Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Minist Environm Protect, Wuhan, Hubei, Peoples R China
4.Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, State Key Lab Environm Hlth Incubat, Wuhan, Hubei, Peoples R China
5.Southern Univ Sci & Technol, Guangdong Prov Key Lab Soil & Groundwater Pollut, Shenzhen 5188055, Guangdong, Peoples R China
6.Southern Univ Sci & Technol, State Environm Protect Key Lab Integrated Surface, Shenzhen 5188055, Guangdong, Peoples R China
7.Educ Univ Hong Kong Baptist, CHEER, Hong Kong, Peoples R China

Fang, Jing,Liu, Hongxiu,Zhao, Hongzhi,et al. Association of prenatal exposure to organochlorine pesticides and birth size[J]. SCIENCE OF THE TOTAL ENVIRONMENT,2019,654:678-683.

Fang, Jing,Liu, Hongxiu,Zhao, Hongzhi,Wong, Minghung,Xu, Shunqing,&Cai, Zongwei.(2019).Association of prenatal exposure to organochlorine pesticides and birth size.SCIENCE OF THE TOTAL ENVIRONMENT,654,678-683.

Fang, Jing,et al."Association of prenatal exposure to organochlorine pesticides and birth size".SCIENCE OF THE TOTAL ENVIRONMENT 654(2019):678-683.