Bisphenol S-induced chronic inflammatory stress in liver via peroxisome proliferator-activated receptor gamma using fish in vivo and in vitro models

Qiu, Wenhui1,2; Yang, Ming3; Liu, Jingyu1,2; Xu, Hai4; Luo, Shusheng1,2; Wong, Minghung1,2,5; Zheng, Chunmiao1,2

2019-03

10.1016/j.envpol.2018.11.039

ENVIRONMENTAL POLLUTION   影响因子和分区

0269-7491

1873-6424

Bisphenol S (BPS) has been widely used as a bisphenol alternative in recent few years. However, with mounting evidence suggesting that the presence of BPS in the environment also poses risks to ecosystems and human health, we decided to use the juvenile common carp (Cyprinus carpio) and its primary macrophages as in vivo and in vitro models to examine if BPS is a safe substitute of BPA. The present study evaluated the immune responses of chronic BPS exposure and their mechanisms of action associated with peroxisome proliferator-activated receptor (PPAR) signaling pathway. Potential oxidative stress and pro-inflammatory effects of BPS exposure were identified in fish liver after 60-day exposure, based on the increased reactive oxygen species (ROS) production, antioxidant capacity, NO production, lipid peroxidation, and induction of inflammatory cytokine expression, as well as acute phase protein levels of C reactive protein, immunoglobulin M, lysozyme, and complement component 3. Moreover, ppary, PPAR gamma pathway-associated genes retinoid x receptor alpha (rxr alpha) and nuclear factor-kappa b (nf kappa b) presented a rough concentration-dependent alteration after BPS exposure. An acute BPS exposure to the isolated primary macrophages from juvenile common carp was performed to help elucidate gene expression patterns of ppar gamma, rxr alpha, and nfKb in a typical immune cell model, the results were consistent with what we found in vivo experiments for long-term BPS exposure. Furthermore, with coexposure to BPS and a PPAR gamma antagonist, the restriction of PPAR signaling pathway significantly inhibited the induction of ROS and the mRNA level of interleukin-1 beta, confirming the involvement of PPAR pathway in BPS-induced chronic inflammatory stress in liver. (C) 2018 Elsevier Ltd. All rights reserved.

Bisphenol S (BPS) Common carp Oxidative stress Pro-inflammatory disturbance Peroxisome proliferator-activated receptor

SCI ; EI

英语

第一 ; 通讯

Southern University of Science and Technology[G01296001]

Environmental Sciences & Ecology

Environmental Sciences

WOS:000458222100109

ELSEVIER SCI LTD

20190206364933

Biomarkers ; Cytology ; Fish ; Gene expression ; Health risks ; Macrophages ; Oxidative stress ; Proteins

Bioengineering and Biology:461 ; Organic Compounds:804.1

ENVIRONMENT/ECOLOGY

Web of Science

1.Southern Univ Sci & Technol, Sch Environm Sci & Engn, Guangdong Prov Key Lab Soil & Groundwater Pollut, Shenzhen 518055, Peoples R China
2.Southern Univ Sci & Technol, Sch Environm Sci & Engn, State Environm Protect Key Lab Integrated Surface, Shenzhen 518055, Peoples R China
3.Shanghai Univ, Sch Environm & Chem Engn, Shanghai 200444, Peoples R China
4.Jiangsu Univ, Sch Environm & Safety Engn, Inst Environm Hlth & Ecol Secur, Zhenjiang 212013, Jiangsu, Peoples R China
5.Educ Univ Hong Kong, Dept Sci & Environm Studies, CHEER, Tai Po, Hong Kong, Peoples R China

Qiu, Wenhui,Yang, Ming,Liu, Jingyu,et al. Bisphenol S-induced chronic inflammatory stress in liver via peroxisome proliferator-activated receptor gamma using fish in vivo and in vitro models[J]. ENVIRONMENTAL POLLUTION,2019,246:963-971.

Qiu, Wenhui.,Yang, Ming.,Liu, Jingyu.,Xu, Hai.,Luo, Shusheng.,...&Zheng, Chunmiao.(2019).Bisphenol S-induced chronic inflammatory stress in liver via peroxisome proliferator-activated receptor gamma using fish in vivo and in vitro models.ENVIRONMENTAL POLLUTION,246,963-971.

Qiu, Wenhui,et al."Bisphenol S-induced chronic inflammatory stress in liver via peroxisome proliferator-activated receptor gamma using fish in vivo and in vitro models".ENVIRONMENTAL POLLUTION 246(2019):963-971.