Multivalent Aminosaccharide-Based Gold Nanoparticles as Narrow-Spectrum Antibiotics in Vivo

Yang, Xinglong1; Wei, Qin1; Shao, Huawu2,3; Jiang, Xingyu1,3,4,5

2019-02-27

10.1021/acsami.8b19658

ACS Applied Materials & Interfaces   影响因子和分区

1944-8244

1944-8252

Bacterial infection, especially multidrug-resistant (MDR) bacteria-induced wound infection, is an enormous challenge and is the result of the inability of traditional antibiotics to combat MDR bacteria produced by the abuse of broad-spectrum drugs. Here, we present multivalent aminosaccharide-based gold nanoparticles (AuNPs) to remedy the superbug-infected wound. We synthesized multivalent aminosaccharide-based AuNPs via a straightforward method using D-glucosamine (G1uN) to modify gold nanoparticles (AuNPs) as reported. This kind of multivalent aminosaccharide-based AuNP (Au_GluN) can lower the bacterial viability in a mature biofilm that may lead to antibiotic resistance. Au_GluN is innocuous not only for erythrocytes in vitro but also for mice. Moreover, it displays an outstanding ability for superbug-infected wound healing. Such a material provides new candidates to treat bacteria in the clinic.

aminosaccharide gold nanoparticles multidrug-resistant bacteria antibacterial activity biofilm

SCI ; EI

英语

通讯

National Science Foundation of China[81361140345] ; National Science Foundation of China[21535001] ; National Science Foundation of China[81730051] ; National Science Foundation of China[21761142006]

Science & Technology - Other Topics ; Materials Science

Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary

WOS:000460365300010

AMER CHEMICAL SOC

20190906548943

Antibiotics ; Bacteria ; Biofilms ; Drug delivery ; Fiber optic sensors ; Mammals ; Metal nanoparticles ; Nanometals ; Synthesis (chemical)

Medicine and Pharmacology:461.6 ; Biomaterials (including synthetics):462.5 ; Fiber Optics:741.1.2 ; Nanotechnology:761 ; Chemical Reactions:802.2

Web of Science

1.Univ Jinan, Sch Chem & Chem Engn, Jinan 250022, Shandong, Peoples R China
2.Chinese Acad Sci, Chengdu Inst Biol, Nat Prod Res Ctr, Chengdu 610041, Sichuan, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Natl Ctr NanoSci & Technol, Beijing Engn Res Ctr BioNanotechnol, CAS Key Lab Biol Effects Nanomat & Nanosafety, CAS Ctr Excellence Nanosci, Beijing 100190, Peoples R China
5.Southern Univ Sci & Technol, Dept Biomed Engn, 1088 Xueyuan Rd, Shenzhen 518055, Guangdong, Peoples R China

Yang, Xinglong,Wei, Qin,Shao, Huawu,et al. Multivalent Aminosaccharide-Based Gold Nanoparticles as Narrow-Spectrum Antibiotics in Vivo[J]. ACS Applied Materials & Interfaces,2019,11(8):7725-7730.

Yang, Xinglong,Wei, Qin,Shao, Huawu,&Jiang, Xingyu.(2019).Multivalent Aminosaccharide-Based Gold Nanoparticles as Narrow-Spectrum Antibiotics in Vivo.ACS Applied Materials & Interfaces,11(8),7725-7730.

Yang, Xinglong,et al."Multivalent Aminosaccharide-Based Gold Nanoparticles as Narrow-Spectrum Antibiotics in Vivo".ACS Applied Materials & Interfaces 11.8(2019):7725-7730.