Polymer Dots Compartmentalized in Liposomes as a Photocatalyst for In Situ Hydrogen Therapy

Zhang, Boyu1,2; Wang, Fei4; Zhou, Hua1; Gao, Duyang3; Yuan, Zhen1; Wu, Changfeng4; Zhang, Xuanjun1

2019-02-25

10.1002/anie.201813066

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION   影响因子和分区

1433-7851

1521-3773

Semiconducting polymer dots (Pdots) have recently attracted considerable attention because of their photocatalytic activity as well as tunable optical band gap. In this contribution, we describe the therapeutic application of Pdots through in situ photocatalytic hydrogen generation. Liposomes were employed as nanoreactors to confine the Pdot photocatalyst, reactants, intermediates, and by-products. Upon photon absorption by the Pdots, the catalytic cycle is initiated and repeated within the aqueous interior, while the H-2 product diffuses across the lipid bilayer to counteract reactive oxygen species (ROS) overexpressed in diseased tissues. Ensemble and single-particle Forster resonance energy transfer microscopy confirmed the proposed nanoreactor model. We demonstrate that a liposomal nanoreactor containing Pdots and a sacrificial electron donor is a potential photocatalytic nanoreactor for in situ hydrogen therapy.

compartmentalization hydrogen therapy liposomes photocatalysis polymer dots

SCI ; EI

英语

NI期刊

通讯

Research Grant of the University of Macau[MYRG2016-00058-FHS] ; Research Grant of the University of Macau[MYRG2017-00066-FHS]

Chemistry

Chemistry, Multidisciplinary

WOS:000459807200031

WILEY-V C H VERLAG GMBH

20190706496259

Energy gap ; Energy transfer ; Hydrogen production ; Lipid bilayers ; Liposomes ; Photocatalysis ; Photocatalytic activity ; Polymers

Biology:461.9 ; Gas Fuels:522 ; Light/Optics:741.1 ; Nanotechnology:761 ; Polymeric Materials:815.1 ; Solid State Physics:933

CHEMISTRY

Web of Science

1.Univ Macau, Fac Hlth Sci, Macau, Peoples R China
2.Dalian Med Univ, Coll Med Lab, Dalian 116044, Liaoning, Peoples R China
3.Chinese Acad Sci, Shenzhen Inst Adv Technol, Inst Biomed & Hlth Engn, Paul C Lauterbur Res Ctr Biomed Imaging, Shenzhen 518055, Peoples R China
4.Southern Univ Sci & Technol, Dept Biomed Engn, Shenzhen 518055, Guangdong, Peoples R China

Zhang, Boyu,Wang, Fei,Zhou, Hua,et al. Polymer Dots Compartmentalized in Liposomes as a Photocatalyst for In Situ Hydrogen Therapy[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2019,58(9):2744-2748.

Zhang, Boyu.,Wang, Fei.,Zhou, Hua.,Gao, Duyang.,Yuan, Zhen.,...&Zhang, Xuanjun.(2019).Polymer Dots Compartmentalized in Liposomes as a Photocatalyst for In Situ Hydrogen Therapy.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,58(9),2744-2748.

Zhang, Boyu,et al."Polymer Dots Compartmentalized in Liposomes as a Photocatalyst for In Situ Hydrogen Therapy".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 58.9(2019):2744-2748.