南方科技大学知识苑(SUSTech KC): GDPLichi: a DNA Damage Repair-Related Gene Classifier for Predicting Lung Adenocarcinoma Immune Checkpoint Inhibitors Response

题名	GDPLichi: a DNA Damage Repair-Related Gene Classifier for Predicting Lung Adenocarcinoma Immune Checkpoint Inhibitors Response
作者	Leng, Yang 1; Dang, Shiying 1; Yin, Fei 2; Gao, Tianshun 1; Xiao, Xing 1; Zhang, Yi 1; Chen, Lin 1; Qin, Changfei 1; Lai, Nannan 1; Zhan, Xiao-Yong 1; Huang, Ke 1; Luo, Chuanming 3; Kang, Yang 1; Wang, Nan 1; Li, Yun 2; Liang, Yuhong4 ; Huang, Bihui 1
通讯作者	Li, Yun; Liang, Yuhong; Huang, Bihui
发表日期	2021-12-02
DOI	10.3389/fonc.2021.733533
发表期刊	Frontiers in Oncology 影响因子和分区
ISSN	2234-943X
卷号	11
摘要	Lung cancer is one of the most common and mortal malignancies, usually with a poor prognosis in its advanced or recurrent stages. Recently, immune checkpoint inhibitors (ICIs) immunotherapy has revolutionized the treatment of human cancers including lung adenocarcinoma (LUAD), and significantly improved patients' prognoses. However, the prognostic and predictive outcomes differ because of tumor heterogeneity. Here, we present an effective method, GDPLichi (Genes of DNA damage repair to predict LUAD immune checkpoint inhibitors response), as the signature to predict the LUAD patient's response to the ICIs. GDPLichi utilized only 7 maker genes from 8 DDR pathways to construct the predictive model and classified LUAD patients into two subgroups: low- and high-risk groups. The high-risk group was featured by worse prognosis and decreased B cells, CD8(+) T cells, CD8(+) central memory T cells, hematopoietic stem cells (HSC), myeloid dendritic cells (MDC), and immune scores as compared to the low-risk group. However, our research also suggests that the high-risk group was more sensitive to ICIs, which might be explained by increased TMB, neoantigen, immune checkpoint molecules, and immune suppression genes' expression, but lower TIDE score as compared to the low-risk group. This conclusion was verified in three other LUAD cohort datasets (GSE30219, GSE31210, GSE50081).
关键词	DNA damage repair (DDR) immune check inhibitor (ICI) GDPLichi lung adenocarcinoma gene classifier
相关链接	[来源记录]
收录类别	SCI
语种	英语
学校署名	通讯
WOS研究方向	Oncology
WOS类目	Oncology
WOS记录号	WOS:000738191000001
出版者	FRONTIERS MEDIA SA
来源库	Web of Science
引用统计	被引频次[WOS]：4
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/264222
专题	南方科技大学医学院
作者单位	1.Sun Yat Sen Univ, Affiliated Hosp 7, Ctr Sci Res, Shenzhen, Peoples R China 2.Sun Yat Sen Univ, Affiliated Hosp 7, Dept Thorac Surg, Shenzhen, Peoples R China 3.Sun Yat Sen Univ, Affiliated Hosp 7, Ctr Clin Neurosci, Shenzhen, Peoples R China 4.Southern Univ Sci & Technol, Sch Med, Shenzhen, Peoples R China
通讯作者单位	南方科技大学医学院
推荐引用方式 GB/T 7714	Leng, Yang,Dang, Shiying,Yin, Fei,et al. GDPLichi: a DNA Damage Repair-Related Gene Classifier for Predicting Lung Adenocarcinoma Immune Checkpoint Inhibitors Response[J]. Frontiers in Oncology,2021,11.
APA	Leng, Yang.,Dang, Shiying.,Yin, Fei.,Gao, Tianshun.,Xiao, Xing.,...&Huang, Bihui.(2021).GDPLichi: a DNA Damage Repair-Related Gene Classifier for Predicting Lung Adenocarcinoma Immune Checkpoint Inhibitors Response.Frontiers in Oncology,11.
MLA	Leng, Yang,et al."GDPLichi: a DNA Damage Repair-Related Gene Classifier for Predicting Lung Adenocarcinoma Immune Checkpoint Inhibitors Response".Frontiers in Oncology 11(2021).