Chondroitin sulfate zinc with antibacterial properties and anti-inflammatory effects for skin wound healing

Wu，Guofeng1,2; Ma，Fenbo2; Xue，Yizhebang2; Peng，Ying2; Hu，Liqiu2; Kang，Xiaowo2; Sun，Qili2; Ouyang，Dong Fang2,3; Tang，Bin1,2,4; Lin，Lijun1

2022-02-15

10.1016/j.carbpol.2021.118996

CARBOHYDRATE POLYMERS   影响因子和分区

0144-8617

A chondroitin sulfate zinc (CSZn) complex was prepared by an ion-exchange method. The purified product was characterized by energy-dispersive X-ray spectroscopy, high-performance chromatography, elemental analysis, Fourier transform infrared spectroscopy, inductively coupled mass spectrometry, and nuclear magnetic resonance spectroscopy. The CSZn demonstrated antibacterial activity against Escherichia coli and Staphylococcus aureus and satisfied MTT cell viability (NIH3T3 fibroblasts) at ≤50 μg/mL. RT-PCR demonstrated significant promotion by CSZn of fibroblast growth factor beta (β-FGF), collagen III (COLIIIα1), vascular endothelial growth factor (VEGF) and reduction of cytokines IL-6, IL-1β & TNF-alpha. An in vivo rat full-thickness wound healing model demonstrated significant wound healing of CSZn relative to controls of saline treatment, zinc chloride treatment and chondroitin treatment. CSZn has demonstrated promising antibacterial and wound healing properties making it deserving of consideration for more advanced wound healing applications.

Anti-inflammatory Chondroitin sulfate zinc Wound healing

EI

英语

通讯

20215111334562

Cell culture ; Chlorine compounds ; Endothelial cells ; Energy dispersive spectroscopy ; Escherichia coli ; Fibroblasts ; Fourier transform infrared spectroscopy ; Ion exchange ; Mass spectrometry ; Nuclear magnetic resonance spectroscopy

Biology:461.9 ; Chemistry:801 ; Chemical Reactions:802.2

CHEMISTRY

2-s2.0-85121101342

Scopus

1.Department of Joint and Orthopedics,Zhujiang Hospital,Southern Medical University,Guangzhou,China
2.Department of Biomedical Engineering,Southern University of Science and Technology,Shenzhen,China
3.Department of Mechanical Engineering,University of Toronto,Canada
4.Guangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research,China

Wu，Guofeng,Ma，Fenbo,Xue，Yizhebang,et al. Chondroitin sulfate zinc with antibacterial properties and anti-inflammatory effects for skin wound healing[J]. CARBOHYDRATE POLYMERS,2022,278.

Wu，Guofeng.,Ma，Fenbo.,Xue，Yizhebang.,Peng，Ying.,Hu，Liqiu.,...&Lin，Lijun.(2022).Chondroitin sulfate zinc with antibacterial properties and anti-inflammatory effects for skin wound healing.CARBOHYDRATE POLYMERS,278.

Wu，Guofeng,et al."Chondroitin sulfate zinc with antibacterial properties and anti-inflammatory effects for skin wound healing".CARBOHYDRATE POLYMERS 278(2022).