Genus Lonicera: New drug discovery from traditional usage to modern chemical and pharmacological research

Ge，Lanlan1,2; Xie，Qiujie1; Jiang，Yuanyuan1; Xiao，Lingyun1; Wan，Haoqiang1,2; Zhou，Boping1; Wu，Shipin1; Tian，Jun3; Zeng，Xiaobin1,2,4

2022-02-01

10.1016/j.phymed.2021.153889

PHYTOMEDICINE   影响因子和分区

0944-7113

1618-095X

Background: Lonicera Linn. belonging to the family Caprifoliaceae, the largest genus in the plant family, includes about more than 200 species, which are mainly distributed in northern Africa, North America, Europe and Asia. Some species of this genus have been usually used in traditional Chinese medicine as well as functional foods, cosmetics and other applications, such as L. japonica Thunb. Bioactive components and pharmacological activities of the genus Lonicera plants have received an increasing interest from the scientific community. Thus, a comprehensive and systematic review on their traditional usage in China, chemical components, and their pharmacological properties of their whole plants, bioactive extracts, and bioactive isolates including partial structure-activity relationships from the genus is indispensable. Methods: Information on genus Lonicera of this systematic electronic literature search was gathered via the published articles, patents, clinical trials website (https://clinicaltrials.gov/) and several online bibliographic databases (PubMed, Sci Finder, Research Gate, Science Direct, CNKI, Web of Science and Google Scholar). The following keywords were used for the online search: Lonicera, phytochemical composition, Lonicerae japonica, Lonicera review articles, bioactivities of Lonicera, anti-inflammatory, antiviral, antimicrobial, anticancer, hepatoprotective, antioxidant, neuroprotective, anti-diabetic, and clinical trials. This review paper consists of a total of 225 papers covering the Lonicera genus from 1800 to 2021, including research articles, reviews, patents, and book chapters. Results: In this review (1800s-2021), about 420 components from the genus of Lonicera Linn. including 87 flavonoids, 222 terpenoids, 51 organic acids, and other compounds, together with their pharmacological activities including anti-inflammatory, antiviral, antimicrobial, anticancer, hepatoprotective, antioxidant, neuroprotective, antidiabetic, anti-allergic, immunomodulatory effects, and toxicity were summarized. Conclusion: The relationship is discussed among their traditional usage, their pharmacological properties, and their chemical components, which indicate the genus Lonicera have a large prospect in terms of new drug exploitation, especially in COVID-19 treatment.

Chemical constituents Genus Lonicera Pharmacological activities Traditional usage

SCI

英语

第一 ; 通讯

National Natural Science Foundation of China[81503221,81903760,81903914] ; Shenzhen Fundamental Research and Discipline Layout Project["JCYJ20170413093108233","JCYJ20190806151816859"] ; Nat-ural Science Foundation of Guangdong Province[2017A030313659]

Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine

Plant Sciences ; Chemistry, Medicinal ; Integrative & Complementary Medicine ; Pharmacology & Pharmacy

WOS:000789701100003

ELSEVIER GMBH

PHARMACOLOGY & TOXICOLOGY

2-s2.0-85121980730

Scopus

1.Center Lab of Longhua Branch and Department of Infectious Disease,Shenzhen People's Hospital The Second Clinical Medical College,Jinan University,The First Affiliated Hospital,Southern University of Science and Technology,Shenzhen,518020,China
2.Department of Pathology (Longhua Branch),Shenzhen People's Hospital The Second Clinical Medical College,Jinan University,The First Affiliated Hospital,Southern University of Science and Technology,Shenzhen,518020,China
3.College of Life Science,Jiangsu Normal University,Xuzhou,221116,China
4.Guangdong Provincial Key Laboratory of Regional Immunity and Diseases,Medicine School of Shenzhen University,Shenzhen,518037,China

Ge，Lanlan,Xie，Qiujie,Jiang，Yuanyuan,et al. Genus Lonicera: New drug discovery from traditional usage to modern chemical and pharmacological research[J]. PHYTOMEDICINE,2022,96.

Ge，Lanlan.,Xie，Qiujie.,Jiang，Yuanyuan.,Xiao，Lingyun.,Wan，Haoqiang.,...&Zeng，Xiaobin.(2022).Genus Lonicera: New drug discovery from traditional usage to modern chemical and pharmacological research.PHYTOMEDICINE,96.

Ge，Lanlan,et al."Genus Lonicera: New drug discovery from traditional usage to modern chemical and pharmacological research".PHYTOMEDICINE 96(2022).