Room-Temperature Harvesting Oxidase-Mimicking Enzymes with Exogenous ROS Generation in One Step

Sun, Zhencheng1; Yao, Jiajian1; Wang, Jidong2; Huang, Ruijia1; Liu, Xiaolei1; Li, Feng1; Jiang, Xingyu3; Chen, Wenwen1

2022

10.1021/acs.inorgchem.1c03514

INORGANIC CHEMISTRY   影响因子和分区

0020-1669

1520-510X

Despite the advantages of low cost, high stability, and activities, a majority of nanozymes rely on strict synthesis conditions and precise size/structure control, hindering the stable, bulk, and high-yield production that is necessary for general use. To facilitate the transition of nanozymes from benchtop to real-world applications, we herein present a one-step approach, which only needs mixing of two broad commercialized reagents at room temperature, to harvest gold nanoparticles-bovine serum albumin (BSA) nanocomposite (BSA-Au) with distinct oxidase-like activity and good stability in a broad range of harsh conditions. Density functional theory (DFT) calculations demonstrate the oxidase-like activity of BSA-Au stemming from thermodynamically and kinetically favored facets for O-2 activation. The reactive oxygen species (ROS) generation of BSA-Au contributes to the catalytic activities and further enables water sterilization and antibacterial applications against superbugs. This one-step strategy promises great potential in bulk production of nanozyme for broad application beyond laboratory use.

SCI ; EI

英语

NI论文

通讯

National Natural Science Foundation of China[22074094] ; Shenzhen Science project[JCYJ20180507182025817]

Chemistry

Chemistry, Inorganic & Nuclear

WOS:000740264300001

AMER CHEMICAL SOC

20220311472350

Catalyst activity ; Costs ; Density functional theory ; Gold nanoparticles

Nanotechnology:761 ; Chemical Agents and Basic Industrial Chemicals:803 ; Chemical Products Generally:804 ; Cost and Value Engineering; Industrial Economics:911 ; Probability Theory:922.1 ; Atomic and Molecular Physics:931.3 ; Quantum Theory; Quantum Mechanics:931.4

CHEMISTRY

Web of Science

1.Shenzhen Univ, Hlth Sci Ctr, Sch Biomed Engn, Shenzhen 518055, Peoples R China
2.Shenzhen Univ, Huazhong Univ Sci & Technol, Hlth Sci Ctr, Affiliated Hosp 6,Union Shenzhen Hosp,Cent Lab, Shenzhen 518052, Peoples R China
3.Southern Univ Sci & Technol, Dept Biomed Engn, Shenzhen 518055, Peoples R China

Sun, Zhencheng,Yao, Jiajian,Wang, Jidong,et al. Room-Temperature Harvesting Oxidase-Mimicking Enzymes with Exogenous ROS Generation in One Step[J]. INORGANIC CHEMISTRY,2022,61(2):1169-1177.

Sun, Zhencheng.,Yao, Jiajian.,Wang, Jidong.,Huang, Ruijia.,Liu, Xiaolei.,...&Chen, Wenwen.(2022).Room-Temperature Harvesting Oxidase-Mimicking Enzymes with Exogenous ROS Generation in One Step.INORGANIC CHEMISTRY,61(2),1169-1177.

Sun, Zhencheng,et al."Room-Temperature Harvesting Oxidase-Mimicking Enzymes with Exogenous ROS Generation in One Step".INORGANIC CHEMISTRY 61.2(2022):1169-1177.