Cancellous-Bone-like Porous Iron Scaffold Coated with Strontium Incorporated Octacalcium Phosphate Nanowhiskers for Bone Regeneration

He, Jin1,2; Ye, Haixia1; Li, Yulei1; Fang, Ju1; Mei, Qingsong2; Lu, Xiong3; Ren, Fuzeng1

2019-02

10.1021/acsbiomaterials.8b01188

ACS Biomaterials Science & Engineering   影响因子和分区

2373-9878

The repair of large bone defects poses a grand challenge in tissue engineering. Thus, developing biocompatible scaffolds with mechanical and structural similarity to human cancellous bone is in great demand. Herein, we fabricated a three-dimensional (3D) porous iron (Fe) scaffold with interconnected pores via a template-assisted electrodeposition method. The porous Fe scaffold with a skeleton diameter of 143 mu m had the porosity >90%, an average pore size of 345 mu m, and a yield strength of 3.5 MPa. Such structure and mechanical strength were close to those of cancellous bone. In order to enhance the biocompatibility of the scaffold, strontium incorporated octacalcium phosphate (Sr-OCP) was coated on the skeletons of the porous Fe scaffold. The coated Sr-OCP was in the form of nanowhiskers with a mean diameter of 300 nm and length of 30 mu m. Such Sr-OCP coating could effectively reduce the release rate of the Fe ions to a level which was safe for the human body. Both in vitro cytotoxicity tests by extraction method and direct contact assay confirmed that the Sr-OCP coating could promote the cell adhesion and substantially enhance the biocompatibility of the porous Fe scaffolds. Thus, the cancellous-bone-like porous structure with compatible mechanical properties and excellent biocompatibility enables the present Sr-OCP coated porous Fe scaffold to be a promising candidate for bone repair and regeneration.

porous iron bone scaffold electrodeposition octacalcium phosphate bone repair

SCI ; EI

英语

第一 ; 通讯

Fundamental Research Program of Shenzhen[JCYJ20170307110418960]

Materials Science

Materials Science, Biomaterials

WOS:000458937900013

AMER CHEMICAL SOC

20190706494200

Scaffolds (biology) ; Strontium compounds ; Coatings ; Scaffolds ; Electrodes ; Repair ; Hydroxyapatite ; Biomechanics ; Electrodeposition ; Cell adhesion ; Iron ; Bone ; Pore size

Construction Equipment:405.1 ; Biomedical Engineering:461.1 ; Biological Materials and Tissue Engineering:461.2 ; Biomechanics, Bionics and Biomimetics:461.3 ; Biology:461.9 ; Immunology:461.9.1 ; Electroplating:539.3.1 ; Iron:545.1 ; Inorganic Compounds:804.2 ; Coating Materials:813.2 ; Maintenance:913.5 ; Physical Properties of Gases, Liquids and Solids:931.2 ; Materials Science:951

Web of Science

1.Southern Univ Sci & Technol, Dept Mat Sci & Engn, Shenzhen 518055, Guangdong, Peoples R China
2.Wuhan Univ, Sch Power & Mech Engn, Wuhan 430072, Hubei, Peoples R China
3.Southwest Jiaotong Univ, Key Lab Adv Technol Mat, Minist Educ, Sch Mat Sci & Engn, Chengdu 610031, Sichuan, Peoples R China

He, Jin,Ye, Haixia,Li, Yulei,et al. Cancellous-Bone-like Porous Iron Scaffold Coated with Strontium Incorporated Octacalcium Phosphate Nanowhiskers for Bone Regeneration[J]. ACS Biomaterials Science & Engineering,2019,5(2):509-518.

He, Jin.,Ye, Haixia.,Li, Yulei.,Fang, Ju.,Mei, Qingsong.,...&Ren, Fuzeng.(2019).Cancellous-Bone-like Porous Iron Scaffold Coated with Strontium Incorporated Octacalcium Phosphate Nanowhiskers for Bone Regeneration.ACS Biomaterials Science & Engineering,5(2),509-518.

He, Jin,et al."Cancellous-Bone-like Porous Iron Scaffold Coated with Strontium Incorporated Octacalcium Phosphate Nanowhiskers for Bone Regeneration".ACS Biomaterials Science & Engineering 5.2(2019):509-518.