A theranostic agent for cancer therapy and imaging in the second near-infrared window

Ma, Zhuoran1; Wan, Hao1; Wang, Weizhi2; Zhang, Xiaodong3,4; Uno, Takaaki5; Yang, Qianglai6; Yue, Jingying1; Gao, Hongpeng1; Zhong, Yeteng1; Tian, Ye1; Sun, Qinchao1; Liang, Yongye6; Dai, Hongjie1

2019-02

10.1007/s12274-018-2210-x

Nano Research   影响因子和分区

1998-0124

1998-0000

Theranostic nanoparticles are integrated systems useful for simultaneous diagnosis and imaging guided delivery of therapeutic drugs, with wide ranging potential applications in the clinic. Here we developed a theranostic nanoparticle (similar to 24 nm size by dynamic light scattering) p-FE-PTX-FA based on polymeric micelle encapsulating an organic dye (FE) fluorescing in the 1,000-1,700 nm second near-infrared (NIR-II) window and an anti-cancer drug paclitaxel. Folic acid (FA) was conjugated to the nanoparticles to afford specific binding to molecular folate receptors on murine breast cancer 4T1 tumor cells. In vivo, the nanoparticles accumulated in 4T1 tumor through both passive and active targeting effect. Under an 808 nm laser excitation, fluorescence detection above 1,300 nm afforded a large Stokes shift, allowing targeted molecular imaging tumor with high signal to background ratios, reaching a high tumor to normal tissue signal ratio (T/NT) of (20.0 +/- 2.3). Further, 4T1 tumors on mice were completed eradicated by paclitaxel released from p-FE-PTA-FA within 20 days of the first injection. Pharmacokinetics and histology studies indicated p-FE-PTX-FA had no obvious toxic side effects to major organs. This represented the first NIR-II theranostic agent developed.

theranostic nanoparticles second near-infrared window fluorescence imaging cancer therapy

SCI ; EI

英语

其他

Shenzhen Peacock Program[KQTD20140630160825828]

Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics

Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied

WOS:000455549200004

TSINGHUA UNIV PRESS

20184105913910

Controlled drug delivery ; Diagnosis ; Diseases ; Drug interactions ; Fluorescence imaging ; Infrared devices ; Laser excitation ; Light scattering ; Mammals ; Micelles ; Molecular imaging ; Nanoparticles ; Oncology ; Tumors

Biological Materials and Tissue Engineering:461.2 ; Medicine and Pharmacology:461.6 ; Light/Optics:741.1 ; Imaging Techniques:746 ; Nanotechnology:761 ; Colloid Chemistry:801.3 ; Physical Chemistry:801.4 ; Solid State Physics:933

Web of Science

1.Stanford Univ, Dept Chem, Stanford, CA 94305 USA
2.Natl Ctr Nanosci & Technol China, CAS Ctr Excellence Nanosci, CAS Key Lab Biomed Effects Nanomat & Nanosafety, CAS Key Lab Standardizat & Measurement Nanotechno, Beijing 100190, Peoples R China
3.Tianjin Univ, Sch Sci, Dept Phys, Tianjin 300350, Peoples R China
4.Tianjin Univ, Sch Sci, Tianjin Key Lab Low Dimens Mat Phys & Preparing T, Tianjin 300350, Peoples R China
5.JSR Corp, Adv Mat Res Labs, 100 Kawajiri Cho, Yokaichi, Mie 5108552, Japan
6.South Univ Sci & Technol China, Dept Mat Sci & Engn, Shenzhen 518055, Peoples R China

Ma, Zhuoran,Wan, Hao,Wang, Weizhi,et al. A theranostic agent for cancer therapy and imaging in the second near-infrared window[J]. Nano Research,2019,12(2):273-279.

Ma, Zhuoran.,Wan, Hao.,Wang, Weizhi.,Zhang, Xiaodong.,Uno, Takaaki.,...&Dai, Hongjie.(2019).A theranostic agent for cancer therapy and imaging in the second near-infrared window.Nano Research,12(2),273-279.

Ma, Zhuoran,et al."A theranostic agent for cancer therapy and imaging in the second near-infrared window".Nano Research 12.2(2019):273-279.