Brain imaging with near-infrared fluorophores

Wang, Hao1,2; Mu, Xiaoyu3,4; Yang, Jiang7,8; Liang, Yongye9; Zhang, Xiao-Dong3,4,5; Ming, Dong6,10

2019-02

10.1016/j.ccr.2018.11.003

COORDINATION CHEMISTRY REVIEWS   影响因子和分区

0010-8545

1873-3840

As the centralized control system of the body, the brain is a complex organ of the utmost importance that even the most minor disorder and trauma can cause inestimable harm. There has always been an unmet clinical need for non-invasive high-resolution imaging techniques without a craniotomy to assist neurosurgeons gain anatomical and functional information for brain examination. Compared to the traditional methods, near-infrared (NIR) imaging (window 1, 700-900 rim; window II, 1000-1700 nm) provides an innovative strategy for non-radioactive inspection with high tempo-spatial resolution. In particular, NIR-II imaging shows longer tissue penetration depths and ultralow tissue backgrounds due to drastically decreased photon scattering and tissue autofluorescence. In the current review, we highlight recent advances in NIR fluorophores, especially their rational design and application in NIR fluorescence imaging of the brain, sorted through brain tumors, traumatic brain injuries and bleeding diseases, as well as neurodegenerative disorders like Alzheimer's and Huntington's diseases. This state-of-the-art, non-invasive and non-radioactive optical imaging modality shows a promising prospect in understanding the fundamental pathophysiology of neurological diseases and is envisioned for potential clinical translation. (C) 2018 Elsevier B.V. All rights reserved.

Near-infrared Fluorophores Brain imaging

SCI

英语

其他

Natural Science Foundation of Tianjin[15JCQNJC45800] ; Natural Science Foundation of Tianjin[17YFZCSY00670] ; Natural Science Foundation of Tianjin[17JCYBJC25800]

Chemistry

Chemistry, Inorganic & Nuclear

WOS:000453492900023

ELSEVIER SCIENCE SA

CHEMISTRY

Web of Science

1.Chinese Acad Med Sci, Inst Radiat Med, Tianjin Key Lab Mol Nucl Med, 238 Baidi Rd, Tianjin 300192, Peoples R China
2.Peking Union Med Coll, 238 Baidi Rd, Tianjin 300192, Peoples R China
3.Tianjin Univ, Sch Sci, Dept Phys, Tianjin 300350, Peoples R China
4.Tianjin Univ, Sch Sci, Tianjin Key Lab Low Dimens Mat Phys & Preparing T, Tianjin 300350, Peoples R China
5.Tianjin Collaborat Innovat Ctr Chem Sci & Engn, Tianjin 300072, Peoples R China
6.Tianjin Univ, Med Coll, Acad Med Engn & Translat Med, Tianjin 300072, Peoples R China
7.Sun Yat Sen Univ, Canc Ctr, Collaborat Innovat Ctr Canc Med, State Key Lab Oncol South China, Guangzhou 510060, Guangdong, Peoples R China
8.Mem Sloan Kettering Canc Ctr, Dept Radiol, 1275 York Ave, New York, NY 10021 USA
9.South Univ Sci & Technol China, Dept Mat Sci & Engn, Shenzhen 518055, Peoples R China
10.Tianjin Univ, Sch Precis Instrument & Optoelect Engn, Dept Biomed Engn, Tianjin 300072, Peoples R China

Wang, Hao,Mu, Xiaoyu,Yang, Jiang,et al. Brain imaging with near-infrared fluorophores[J]. COORDINATION CHEMISTRY REVIEWS,2019,380:550-571.

Wang, Hao,Mu, Xiaoyu,Yang, Jiang,Liang, Yongye,Zhang, Xiao-Dong,&Ming, Dong.(2019).Brain imaging with near-infrared fluorophores.COORDINATION CHEMISTRY REVIEWS,380,550-571.

Wang, Hao,et al."Brain imaging with near-infrared fluorophores".COORDINATION CHEMISTRY REVIEWS 380(2019):550-571.