Diverse biological characteristics and varied virulence of H7N9 from Wave 5

Bao, Linlin1,2,3; Bi, Yuhai4,5; Wong, Gary4,6; Qi, Wenbao7; Li, Fengdi1,2,3; Lv, Qi1,2,3; Wang, Liang5; Liu, Fei5; Yang, Yang4; Zhang, Cheng5; Liu, William J.8; Quan, Chuansong8; Jia, Weixin7; Liu, Yingxia4; Liu, Wenjun5; Liao, Ming7; Gao, George F.4,5,8; Qin, Chuan1,2,3

2019-01-16

10.1080/22221751.2018.1560234

Emerging Microbes & Infections   影响因子和分区

2222-1751

There was a substantial increase with infections of H7N9 avian influenza virus (AIV) in humans during Wave 5 (2016-2017). To investigate whether H7N9 had become more infectious/transmissible and pathogenic overall, we characterized the receptor binding and experimentally infected ferrets with highly pathogenic (HP)- and low pathogenic (LP)-H7N9 isolates selected from Wave 5, and compared their pathogenicity and transmissibility with a Wave 1 isolate from 2013. Studies show that A/Anhui/1/2013 (LP) and A/Chicken/Heyuan/16876/2016 (HP) were highly virulent in ferrets, A/Guangdong/Th008/2017 (HP) and A/Chicken/Huizhou/HZ-3/2017 (HP) had moderate virulence and A/Shenzhen/Th001/2016 (LP) was of low virulence in ferrets. Transmission was observed only in ferrets infected with A/Anhui/1/2013 and A/Chicken/Heyuan/16876/2016, consistent with the idea that sicker ferrets had a higher probability to transmit virus to naive animals. Given the Varied virulence and transmissibility observed in circulating H7N9 viruses from Wave 5, we conclude that the current public health risk of H7N9 has not substantially increased compared to 2013 and the circulating viruses are quite diverse.

H7N9 influenza receptor ferret pathogenicity transmissibility

SCI

英语

通讯

Youth Innovation Promotion Association of Chinese Academy of Sciences (CAS)[2017122]

Immunology ; Microbiology

Immunology ; Microbiology

WOS:000455807500010

TAYLOR & FRANCIS LTD

Web of Science

1.PUMC, Chinese Acad Med Sci, Inst Lab Anim Sci, Beijing, Peoples R China
2.PUMC, Comparat Med Ctr, Beijing, Peoples R China
3.Minist Hlth, Beijing Key Lab Anim Models Emerging & Reemerging, Key Lab Human Dis Comparat Med, Beijing, Peoples R China
4.Southern Univ Sci & Technol, Shenzhen Key Lab Pathogen & Immun,Hosp 2, State Key Discipline Infect Dis,Shenzhen Peoples, Guangdong Key Lab Diag & Treatment Emerging Infec, Shenzhen, Peoples R China
5.Chinese Acad Sci, Ctr Influenza Res & Early Warning CASCIRE, Collaborat Innovat Ctr Diag & Treatment Infect Di, CAS Key Lab Pathogen Microbiol & Immunol,Inst Mic, Beijing, Peoples R China
6.Univ Laval, Dept Microbiol Infectiol & Immunol, Quebec City, PQ, Canada
7.South China Agr Univ, Coll Vet Med, Natl & Reg Joint Engn Lab Medicament Zoonoses Pre, Guangzhou, Guangdong, Peoples R China
8.Chinese Ctr Dis Control & Prevent China CDC, Natl Inst Viral Dis Control & Prevent, Beijing, Peoples R China

Bao, Linlin,Bi, Yuhai,Wong, Gary,et al. Diverse biological characteristics and varied virulence of H7N9 from Wave 5[J]. Emerging Microbes & Infections,2019,8(1):94-102.

Bao, Linlin.,Bi, Yuhai.,Wong, Gary.,Qi, Wenbao.,Li, Fengdi.,...&Qin, Chuan.(2019).Diverse biological characteristics and varied virulence of H7N9 from Wave 5.Emerging Microbes & Infections,8(1),94-102.

Bao, Linlin,et al."Diverse biological characteristics and varied virulence of H7N9 from Wave 5".Emerging Microbes & Infections 8.1(2019):94-102.