南方科技大学知识苑(SUSTech KC): Enantioselective Construction of Pyridine N-Oxides Featuring 2,3-Dihydrofuran Motifs via Phosphine-Catalyzed [4+1]-Annulation of 2-Enoylpyridine N-Oxides with Morita-Baylis-Hillman Carbonates

题名	Enantioselective Construction of Pyridine N-Oxides Featuring 2,3-Dihydrofuran Motifs via Phosphine-Catalyzed [4+1]-Annulation of 2-Enoylpyridine N-Oxides with Morita-Baylis-Hillman Carbonates
作者	Zhang, Pengfei1,2,3 ; Guo, Xing2,3 ; Liu, Chang 2,3 ; Li, Wenjun 4; Li, Pengfei2,3
通讯作者	Li, Wenjun; Li, Pengfei
发表日期	2019-01-04
DOI	10.1021/acs.orglett.8b03612
发表期刊	ORGANIC LETTERS 影响因子和分区
ISSN	1523-7060
EISSN	1523-7052
卷号	21 期号:1页码:152-155
摘要	The first example of phosphine-catalyzed enantioselective [4 + 1] annulations between 2-enoylpyridine N-oxides and Morita-Baylis-Hillman carbonates is described. When 1,2-bis[(2R,5R)-2,5-dimethylphospholano]benzene monoxide is employed as organocatalyst, Morita-Baylis-Hillman carbonates react with 2-enoylpyridine N-oxides smoothly to afford a series of optically active 2,3-dihydrofurans in high yields (up to 96%) with excellent stereoselectivities (96 -> 99% ee and >20:1 dr). Importantly, the method offers a facile synthetic approach to enantioenriched pyridine N-oxides featuring 2,3-dihydrofuran motifs.
相关链接	[来源记录]
收录类别	SCI ; IC ; CCR
语种	英语
重要成果	NI论文
学校署名	通讯
资助项目	Shenzhen Nobel Prize Scientists Laboratory Project[C17783101]
WOS研究方向	Chemistry
WOS类目	Chemistry, Organic
WOS记录号	WOS:000455285800033
出版者	AMER CHEMICAL SOC
ESI学科分类	CHEMISTRY
来源库	Web of Science
引用统计	被引频次[WOS]：46
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/26631
专题	理学院_化学系深圳格拉布斯研究院
作者单位	1.Harbin Inst Technol, Sch Chem & Chem Engn, Harbin 150080, Heilongjiang, Peoples R China 2.Southern Univ Sci & Technol, Dept Chem, Shenzhen 518055, Peoples R China 3.Southern Univ Sci & Technol, Shenzhen Grubbs Inst, Shenzhen 518055, Peoples R China 4.Qingdao Univ, Dept Med Chem, Sch Pharm, Qingdao 266021, Peoples R China
第一作者单位	化学系; 深圳格拉布斯研究院
通讯作者单位	化学系; 深圳格拉布斯研究院
推荐引用方式 GB/T 7714	Zhang, Pengfei,Guo, Xing,Liu, Chang,et al. Enantioselective Construction of Pyridine N-Oxides Featuring 2,3-Dihydrofuran Motifs via Phosphine-Catalyzed [4+1]-Annulation of 2-Enoylpyridine N-Oxides with Morita-Baylis-Hillman Carbonates[J]. ORGANIC LETTERS,2019,21(1):152-155.
APA	Zhang, Pengfei,Guo, Xing,Liu, Chang,Li, Wenjun,&Li, Pengfei.(2019).Enantioselective Construction of Pyridine N-Oxides Featuring 2,3-Dihydrofuran Motifs via Phosphine-Catalyzed [4+1]-Annulation of 2-Enoylpyridine N-Oxides with Morita-Baylis-Hillman Carbonates.ORGANIC LETTERS,21(1),152-155.
MLA	Zhang, Pengfei,et al."Enantioselective Construction of Pyridine N-Oxides Featuring 2,3-Dihydrofuran Motifs via Phosphine-Catalyzed [4+1]-Annulation of 2-Enoylpyridine N-Oxides with Morita-Baylis-Hillman Carbonates".ORGANIC LETTERS 21.1(2019):152-155.