Mussel-Inspired Contact-Active Antibacterial Hydrogel with High Cell Affinity, Toughness, and Recoverability

Gan, Donglin1; Xu, Tong1; Xing, Wensi1; Ge, Xiang2; Fang, Liming3; Wang, Kefeng4; Ren, Fuzeng5; Lu, Xiong1

2019-01-04

10.1002/adfm.201805964

ADVANCED FUNCTIONAL MATERIALS   影响因子和分区

1616-301X

1616-3028

Antibacterial hydrogel has received extensive attention in soft tissue repair, especially preventing infections those associated with impaired wound healing. However, it is challenging in developing an inherent antibacterial hydrogel integrating with excellent cell affinity and superior mechanical properties. Inspired by the mussel adhesion chemistry, a contact-active antibacterial hydrogel is proposed by copolymerization of methacrylamide dopamine (MADA) and 2-(dimethylamino)ethyl methacrylate and forming an interpenetrated network with quaternized chitosan. The reactive catechol groups of MADA endow the hydrogel with contact intensified bactericidal activity, because it increases the exposure of bacterial cells to the positively charged groups of the hydrogel and strengthens the bactericidal effect. MADA also maintains the good adhesion of fibroblasts to the hydrogel. Moreover, the hybrid chemical and physical cross-links inner the hydrogel network makes the hydrogel strong and tough with good recoverability. In vitro and in vivo tests demonstrate that this tough and contact-active antibacterial hydrogel is a promising material to fulfill the dual functions of promoting tissue regeneration and preventing bacterial infection for wound-healing applications.

contact-active antibacterial mussel inspired tough hydrogel wound healing

SCI ; EI

英语

NI论文 ; ESI高被引

其他

Independent Innovation Fund of Tianjin University[2018XGP-0030]

Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics

Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter

WOS:000454703900006

WILEY-V C H VERLAG GMBH

20184606077905

Adhesion ; Amines ; Bactericides ; Biomechanics ; Cell culture ; Mechanical properties ; Molluscs ; Tissue ; Tissue regeneration

Bioengineering and Biology:461 ; Marine Science and Oceanography:471 ; Chemical Products Generally:804 ; Organic Compounds:804.1 ; Materials Science:951

MATERIALS SCIENCE

Web of Science

1.Southwest Jiaotong Univ, Sch Mat Sci & Engn, Minist Educ, Key Lab Adv Technol Mat, Chengdu 610031, Sichuan, Peoples R China
2.Tianjin Univ, Sch Mech Engn, Minist Educ, Key Lab Mech Theory & Equipment Design, Tianjin 300354, Peoples R China
3.South China Univ Technol, Sch Mat Sci & Engn, Dept Polymer Sci & Engn, Guangzhou 510541, Guangdong, Peoples R China
4.Sichuan Univ, Natl Engn Res Ctr Biomat, Chengdu 610064, Sichuan, Peoples R China
5.Southern Univ Sci & Technol, Dept Mat Sci & Engn, Shenzhen 518055, Guangdong, Peoples R China

Gan, Donglin,Xu, Tong,Xing, Wensi,et al. Mussel-Inspired Contact-Active Antibacterial Hydrogel with High Cell Affinity, Toughness, and Recoverability[J]. ADVANCED FUNCTIONAL MATERIALS,2019,29(1).

Gan, Donglin.,Xu, Tong.,Xing, Wensi.,Ge, Xiang.,Fang, Liming.,...&Lu, Xiong.(2019).Mussel-Inspired Contact-Active Antibacterial Hydrogel with High Cell Affinity, Toughness, and Recoverability.ADVANCED FUNCTIONAL MATERIALS,29(1).

Gan, Donglin,et al."Mussel-Inspired Contact-Active Antibacterial Hydrogel with High Cell Affinity, Toughness, and Recoverability".ADVANCED FUNCTIONAL MATERIALS 29.1(2019).