Transposable elements are regulated by context-specific patterns of chromatin marks in mouse embryonic stem cells

He, Jiangping1,2,3,4,5,6; Fu, Xiuling7; Zhang, Meng1,2,3,4,5,6,8; He, Fangfang7; Li, Wenjuan3,4,8; Abdul, Mazid Md1,2,3,4,5,6,8; Zhou, Jianguo1,2,3,4,5,8; Sun, Li7; Chang, Chen7; Li, Yuhao7; Liu, He1,2; Wu, Kaixin1,2; Babarinde, Isaac A.7; Zhuang, Qiang7,9,10; Loh, Yuin-Han11,12; Chen, Jiekai1,2,3,4,5; Esteban, Miguel A.1,2,3,4,5,8; Hutchins, Andrew P.7

2019-01-03

10.1038/s41467-018-08006-y

Nature Communications   影响因子和分区

2041-1723

The majority of mammalian genomes are devoted to transposable elements (TEs). Whilst TEs are increasingly recognized for their important biological functions, they are a potential danger to genomic stability and are carefully regulated by the epigenetic system. However, the full complexity of this regulatory system is not understood. Here, using mouse embryonic stem cells, we show that TEs are suppressed by heterochromatic marks like H3K9me3, and are also labelled by all major types of chromatin modification in complex patterns, including bivalent activatory and repressive marks. We identified 29 epigenetic modifiers that significantly deregulated at least one type of TE. The loss of Setdbl, Ncor2, Rnf2, Kat5, Prmt5, Uhrfl, and Rrp8 caused widespread changes in TE expression and chromatin accessibility. These effects were context-specific, with different chromatin modifiers regulating the expression and chromatin accessibility of specific subsets of TEs. Our work reveals the complex patterns of epigenetic regulation of TEs.

SCI

英语

NI论文

通讯

Science and Technology Planning Project of Guangdong Province[2017B030314056]

Science & Technology - Other Topics

Multidisciplinary Sciences

WOS:000454756900011

NATURE PUBLISHING GROUP

Web of Science

1.Chinese Acad Sci, Key Lab Regenerat Biol, Guangzhou 510530, Guangdong, Peoples R China
2.Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Guangdong Prov Key Lab Stem Cell & Regenerat Med, Guangzhou 510530, Guangdong, Peoples R China
3.Guangzhou Med Univ, Joint Sch Life Sci, Guangzhou 511436, Guangdong, Peoples R China
4.Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Guangzhou 511436, Guangdong, Peoples R China
5.Guangzhou Regenerat Med & Hlth Guangdong Lab GRMH, Guangzhou 510530, Guangdong, Peoples R China
6.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
7.Southern Univ Sci & Technol, Dept Biol, 1088 Xueyuan Lu, Shenzhen 518055, Peoples R China
8.Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Lab RNA Chromatin & Human Dis, Guangzhou 510530, Guangdong, Peoples R China
9.Nankai Univ, State Key Lab Med Chem Biol, Tianjin 300071, Peoples R China
10.Nankai Univ, Coll Life Sci, Tianjin 300071, Peoples R China
11.ASTAR, Inst Mol & Cell Biol, Epigenet & Cell Fates Lab, 61 Biopolis Dr Proteos, Singapore 138673, Singapore
12.Natl Univ Singapore, Dept Biol Sci, Singapore 117543, Singapore

He, Jiangping,Fu, Xiuling,Zhang, Meng,et al. Transposable elements are regulated by context-specific patterns of chromatin marks in mouse embryonic stem cells[J]. Nature Communications,2019,10.

He, Jiangping.,Fu, Xiuling.,Zhang, Meng.,He, Fangfang.,Li, Wenjuan.,...&Hutchins, Andrew P..(2019).Transposable elements are regulated by context-specific patterns of chromatin marks in mouse embryonic stem cells.Nature Communications,10.

He, Jiangping,et al."Transposable elements are regulated by context-specific patterns of chromatin marks in mouse embryonic stem cells".Nature Communications 10(2019).