| 题名 | Mechano-regulation of proline metabolism and cancer progression by kindlin-2 |
| 作者 | |
| 发表日期 | 2019
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| DOI | |
| 发表期刊 | |
| ISSN | 2372-3556
|
| EISSN | 2372-3548
|
| 卷号 | 6期号:3 |
| 摘要 | Alterations of cell mechano-environment and metabolism are common features of malignant neoplasm. We recently showed that increased stiffness of extracellular matrix is intrinsically linked to up-regulation of proline synthesis through a mechano-responsive fermitin family homolog 2 (FERMT2, best known as kindlin-2) and pyrroline-5-carboxylate reductase 1(PYCR1) complex, which in turn promotes collagen matrix synthesis, cell proliferation, survival, and cancer progression. |
| 关键词 | |
| 相关链接 | [来源记录] |
| 收录类别 | |
| 语种 | 英语
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| 学校署名 | 第一
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| WOS研究方向 | Oncology
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| WOS类目 | Oncology
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| WOS记录号 | WOS:000469964400010
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| 出版者 | |
| 来源库 | Web of Science
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| 引用统计 |
被引频次[WOS]：6
|
| 成果类型 | 期刊论文 |
| 条目标识符 | http://sustech.caswiz.com/handle/2SGJ60CL/26645 |
| 专题 | 生命科学学院_生物系 前沿与交叉科学研究院 |
| 作者单位 | 1.Southern Univ Sci & Technol, Acad Adv Interdisciplinary Studies, Guangdong Prov Key Lab Cell Microenvironm & Dis R, Shenzhen Key Lab Cell Microenvironm, Shenzhen, Peoples R China; 2.Southern Univ Sci & Technol, Dept Biol, Shenzhen, Peoples R China; 3.Univ Pittsburgh, Dept Pathol, Sch Med, Pittsburgh, PA 15261 USA; 4.Univ Pittsburgh, Canc Inst, Pittsburgh, PA 15261 USA |
| 第一作者单位 | 生物系; 前沿与交叉科学研究院 |
| 第一作者的第一单位 | 生物系; 前沿与交叉科学研究院 |
| 推荐引用方式 GB/T 7714 |
Guo, Ling,Wu, Chuanyue. Mechano-regulation of proline metabolism and cancer progression by kindlin-2[J]. Molecular & Cellular Oncology,2019,6(3).
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| APA |
Guo, Ling,&Wu, Chuanyue.(2019).Mechano-regulation of proline metabolism and cancer progression by kindlin-2.Molecular & Cellular Oncology,6(3).
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| MLA |
Guo, Ling,et al."Mechano-regulation of proline metabolism and cancer progression by kindlin-2".Molecular & Cellular Oncology 6.3(2019).
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| 条目包含的文件 | 条目无相关文件。 | |||||
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