miR-128 suppresses bleomycin-induced pulmonary fibrosis and epithelial to mesenchymal transition by targeting Cadherin-11

Cheng, Han-Rong1; Li, Dong-Cai3,4; Chen, Li1; Hu, Tian-Yong3,4; Deng, Zhu-Hui3,4; Wu, Ben-Qing2

2019

International Journal of Clinical and Experimental Medicine   影响因子和分区

1940-5901

Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease characterized by the replacement of normal lung parenchyma with fibrotic tissue. Epithelial to mesenchymal transition (EMT), due to its close relationship with the process of tissue fibrosis, has been reported to play a crucial role in regulation of pulmonary fibrosis. Recently, miR-128, a brain-enriched microRNA, has been reported to be involved in EMT and tumorigenesis. However, the roles of miR-128 in pulmonary fibrosis have not yet been studied. The current study reports, for the first time, that miR-128 is downregulated in bleomycin (BLM)-induced pulmonary fibrosis and overexpression of it could significantly inhibit the progression of pulmonary fibrosis and EMT. Furthermore, this study shows that CDH11, a crucial regulator in progression of pulmonary fibrosis, is a direct target of miR-128. This direct interaction is crucial for their function in BLM-induced EMT and pulmonary fibrosis. Moreover, present results reveal that upregulation of miR-128 could prevent BLM-induced pulmonary fibrosis and EMT in vitro and in vivo. Taken together, the current study indicates that miR-128 may be a potential therapeutic target for treatment of IPF.

Idiopathic pulmonary fibrosis microRNA miR-128 epithelial to mesenchymal transition Cadherin-11

SCI

英语

第一

Research & Experimental Medicine

Medicine, Research & Experimental

WOS:000462755200042

E-CENTURY PUBLISHING CORP

Web of Science

1.Jinan Univ, Clin Med Coll 2, Southern Univ Sci & Technol, Dept Pediat,Shenzhen Peoples Hosp,Affiliated Hosp, Shenzhen 518020, Peoples R China
2.Guangming New Dist Med Grp, Childrens Med Ctr, Shenzhen 518020, Peoples R China
3.Longgang ENT Hosp, Inst ENT, Shenzhen 518020, Guangdong, Peoples R China
4.Longgang ENT Hosp, Shenzhen Key Lab ENT, Shenzhen 518020, Guangdong, Peoples R China

Cheng, Han-Rong,Li, Dong-Cai,Chen, Li,et al. miR-128 suppresses bleomycin-induced pulmonary fibrosis and epithelial to mesenchymal transition by targeting Cadherin-11[J]. International Journal of Clinical and Experimental Medicine,2019,12(3):2477-2485.

Cheng, Han-Rong,Li, Dong-Cai,Chen, Li,Hu, Tian-Yong,Deng, Zhu-Hui,&Wu, Ben-Qing.(2019).miR-128 suppresses bleomycin-induced pulmonary fibrosis and epithelial to mesenchymal transition by targeting Cadherin-11.International Journal of Clinical and Experimental Medicine,12(3),2477-2485.

Cheng, Han-Rong,et al."miR-128 suppresses bleomycin-induced pulmonary fibrosis and epithelial to mesenchymal transition by targeting Cadherin-11".International Journal of Clinical and Experimental Medicine 12.3(2019):2477-2485.