Ultrasmall hybrid protein-copper sulfide nanoparticles for targeted photoacoustic imaging of orthotopic hepatocellular carcinoma with a high signal-to-noise ratio

Yan, Huixiang1,2; Chen, Jingqin2,3; Li, Ying4; Bai, Yuanyuan2; Wu, Yunzhu1; Sheng, Zonghai5; Song, Liang2; Liu, Chengbo2; Zhang, Hai1,6

2019-01

10.1039/c8bm00767e

Biomaterials Science   影响因子和分区

2047-4830

2047-4849

Although photoacoustic imaging combined with second near infrared (NIR II) molecular probes for tumor diagnosis has drawn tremendous attention during the past few decades, the targeted photoacoustic imaging of orthotopic hepatocellular carcinoma (HCC) still remains a challenge due to high liver vascularization and non-specificity of probes in liver tumors. Herein, we report on cyclic arginine-glycine-aspartic acid (cRGD) peptide conjugated ultrasmall CuS nanoparticles (CuS@BSA-RGD NPs) which encapsulate bovine serum albumin (BSA) and possess high optical absorption at 1064 nm. The encapsulation of BSA results in great biocompatibility of CuS@BSA-RGD NPs along with excellent photostability and physiological stability. The cRGD conjugation enables the improvement of tumor uptake of CuS@BSA-RGD NPs by virtue of its positive tumor cell targeting capability. The efficient accumulation of CuS@BSA-RGD NPs in the tumor over time after intravenous administration to orthotopic HCC bearing mice was achieved, which resulted in highly sensitive photoacoustic visualization of the tumor region. Toxicity studies indicate that CuS@BSA-RGD NPs exhibited negligible systemic toxicity in vivo. The results demonstrate that the CuS@BSA-RGD NPs might hold great promise for future imaging and diagnosis of cancer.

SCI ; EI

英语

通讯

Guangzhou Science and Technology Innovation[201604020144]

Materials Science

Materials Science, Biomaterials

WOS:000454085700035

ROYAL SOC CHEMISTRY

20185206293057

Amino acids ; Biocompatibility ; Body fluids ; Diagnosis ; Infrared devices ; Light absorption ; Mammals ; Nanoparticles ; Photoacoustic effect ; Probes ; Signal to noise ratio ; Sulfur compounds ; Toxicity ; Tumors

Bioengineering and Biology:461 ; Information Theory and Signal Processing:716.1 ; Light/Optics:741.1 ; Nanotechnology:761 ; Organic Compounds:804.1 ; Solid State Physics:933

Web of Science

1.Jinan Univ, Shenzhen Peoples Hosp, Clin Coll 2, Dept Ultrasound, Shenzhen 518020, Peoples R China
2.Chinese Acad Sci, Shenzhen Inst Adv Technol, Inst Biomed & Hlth Engn, Res Lab Biomed Opt & Mol Imaging,Shenzhen Key Lab, Shenzhen 518055, Peoples R China
3.Univ Chinese Acad Sci, Shenzhen Coll Adv Technol, Shenzhen 518055, Peoples R China
4.Univ Hong Kong, Shenzhen Hosp, Dept Med, Div Radiol, Hong Kong, Peoples R China
5.Chinese Acad Sci, Shenzhen Inst Adv Technol, Inst Biomed & Hlth Engn, Paul C Lauterbur Res Ctr Biomed Imaging, Shenzhen 518055, Peoples R China
6.Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen Peoples Hosp, Shenzhen Med Ultrasound Engn Ctr,Dept Ultrasound, Shenzhen 518020, Peoples R China

Yan, Huixiang,Chen, Jingqin,Li, Ying,et al. Ultrasmall hybrid protein-copper sulfide nanoparticles for targeted photoacoustic imaging of orthotopic hepatocellular carcinoma with a high signal-to-noise ratio[J]. Biomaterials Science,2019,7(1):92-103.

Yan, Huixiang.,Chen, Jingqin.,Li, Ying.,Bai, Yuanyuan.,Wu, Yunzhu.,...&Zhang, Hai.(2019).Ultrasmall hybrid protein-copper sulfide nanoparticles for targeted photoacoustic imaging of orthotopic hepatocellular carcinoma with a high signal-to-noise ratio.Biomaterials Science,7(1),92-103.

Yan, Huixiang,et al."Ultrasmall hybrid protein-copper sulfide nanoparticles for targeted photoacoustic imaging of orthotopic hepatocellular carcinoma with a high signal-to-noise ratio".Biomaterials Science 7.1(2019):92-103.