Near-infrared light-regulated cancer theranostic nanoplatform based on aggregation-induced emission luminogen encapsulated upconversion nanoparticles

Jin, Guorui1,2; He, Rongyan1,2; Liu, Qian1,2; Lin, Min1,2; Dong, Yuqing2,3; Li, Kai4; Tang, Ben Zhong5,6,7; Liu, Bin8; Xu, Feng1,2

2019

10.7150/thno.30174

Theranostics   影响因子和分区

1838-7640

Photodynamic therapy (PDT) has been widely applied in the clinic for the treatment of various types of cancer due to its precise controllability, minimally invasive approach and high spatiotemporal accuracy as compared with conventional chemotherapy. However, the porphyrin-based photosensitizers (PSs) used in clinics generally suffer from aggregation-caused reductions in the generation of reactive oxygen species (ROS) and limited tissue penetration because of visible light activation, which greatly hampers their applications for the treatment of deep-seated tumors.

aggregation-induced emission (AIE) photodynamic therapy near infrared light active targeting tumor imaging

SCI

英语

其他

Fundamental Research Funds for the Central Universities[xjj2016081]

Research & Experimental Medicine

Medicine, Research & Experimental

WOS:000453827100005

IVYSPRING INT PUBL

Web of Science

1.Xi An Jiao Tong Univ, Sch Life Sci & Technol, Minist Educ, Key Lab Biomed Informat Engn, Xian 710049, Shaanxi, Peoples R China
2.Xi An Jiao Tong Univ, BEBC, Xian 710049, Shaanxi, Peoples R China
3.Xi An Jiao Tong Univ, Sch Mat Sci & Engn, State Key Lab Mech Behav Mat, Xian 710049, Shaanxi, Peoples R China
4.Southern Univ Sci & Technol, Dept Biomed Engn, Shenzhen 510855, Guangdong, Peoples R China
5.Hong Kong Univ Sci & Technol, Div Life Sci, Div Biomed Engn, Dept Chem,Inst Adv Study,Inst Mol Funct Mat, Hong Kong, Peoples R China
6.Hong Kong Univ Sci & Technol, State Key Lab Mol Neurosci, Kowloon, Hong Kong, Peoples R China
7.South China Univ Technol, State Key Lab Luminescent Mat & Devices, SCUT HKUST Joint Res Lab, Guangdong Innovat Res Team, Guangzhou 510640, Guangdong, Peoples R China
8.Natl Univ Singapore, Dept Chem & Biomol Engn, 4 Engn Dr 4, Singapore 117585, Singapore

Jin, Guorui,He, Rongyan,Liu, Qian,et al. Near-infrared light-regulated cancer theranostic nanoplatform based on aggregation-induced emission luminogen encapsulated upconversion nanoparticles[J]. Theranostics,2019,9(1):246-264.

Jin, Guorui.,He, Rongyan.,Liu, Qian.,Lin, Min.,Dong, Yuqing.,...&Xu, Feng.(2019).Near-infrared light-regulated cancer theranostic nanoplatform based on aggregation-induced emission luminogen encapsulated upconversion nanoparticles.Theranostics,9(1),246-264.

Jin, Guorui,et al."Near-infrared light-regulated cancer theranostic nanoplatform based on aggregation-induced emission luminogen encapsulated upconversion nanoparticles".Theranostics 9.1(2019):246-264.