Efficient lung cancer-targeted drug delivery via a nanoparticle/MSC system

Wang, Xusheng1; Chen, Haiyan2; Zeng, Xiaowei1; Guo, Wenpeng3; Jin, Yu3; Wang, Shan4; Tian, Ruiyun4; Han, Yanjiang5; Guo, Ling6,7; Han, Jimin4; Wu, Yaojiong2,4; Mei, Lin1

2019-01

10.1016/j.apsb.2018.08.006

Acta Pharmaceutica Sinica B   影响因子和分区

2211-3835

2211-3843

Low targeting efficiency limits the applications of nanoparticles in cancer therapy. The fact that mesenchymal stem cells (MSC) trapped in the lung after systemic infusion is a disadvantage for cell therapy purposes. Here, we utilized MSC as lung cancer-targeted drug delivery vehicles by loading nanoparticles (NP) with anti-cancer drug. MSC showed a higher drug intake capacity than fibroblasts. In addition, MSC showed predominant lung trapping in both rabbit and monkey. IR-780 dye, a fluorescent probe used to represent docetaxel (DTX) in NP, delivered via MSC accumulated in the lung. Both in vitro MSC/A549 cell experiments and in vivo MSC/lung cancer experiments validated the intercellular transportation of NP between MSC and cancer cells. In vivo assays showed that the MSC/NP/DTX drug delivery system exerted primary tumor inhibition efficiency similar to that of a NP/DTX drug system. Collectively, the MSC/NP drug delivery system is promising for lung-targeted drug delivery for the treatment of lung cancer and other lung-related diseases. (C) 2019 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Mesenchymal stem cells Nanoparticle Drug delivery Kras(G12D) Lung cancer

SCI

英语

其他

Guangdong Province Medical Science and Technology Research Fund (China)[A2016445]

Pharmacology & Pharmacy

Pharmacology & Pharmacy

WOS:000457201700016

INST MATERIA MEDICA, CHINESE ACAD MEDICAL SCIENCES

Web of Science

QKH20192019102400048303

1.Sun Yat Sen Univ, Sch Pharmaceut Sci Shenzhen, Guangzhou 510275, Guangdong, Peoples R China
2.Tsinghua Univ, TBSI, Shenzhen 518055, Peoples R China
3.Shenzhen Univ, Shenzhen Peoples Hosp 2, Affiliated Hosp 1, Shenzhen 518000, Peoples R China
4.Tsinghua Univ, Sch Life Sci, Beijing 100084, Peoples R China
5.Southern Med Univ, Nanfang Hosp, NanFang PET CT Ctr, Guangzhou 510515, Guangdong, Peoples R China
6.South Univ Sci & Technol China, Dept Biol, Shenzhen 518055, Peoples R China
7.South Univ Sci & Technol China, Shenzhen Key Lab Cell Microenvironm, Shenzhen 518055, Peoples R China

Wang, Xusheng,Chen, Haiyan,Zeng, Xiaowei,et al. Efficient lung cancer-targeted drug delivery via a nanoparticle/MSC system[J]. Acta Pharmaceutica Sinica B,2019,9(1):167-176.

Wang, Xusheng.,Chen, Haiyan.,Zeng, Xiaowei.,Guo, Wenpeng.,Jin, Yu.,...&Mei, Lin.(2019).Efficient lung cancer-targeted drug delivery via a nanoparticle/MSC system.Acta Pharmaceutica Sinica B,9(1),167-176.

Wang, Xusheng,et al."Efficient lung cancer-targeted drug delivery via a nanoparticle/MSC system".Acta Pharmaceutica Sinica B 9.1(2019):167-176.