Continued reassortment of avian H6 influenza viruses from Southern China, 2014-2016

Li, Juan1; Quan, Chuansong2,3; Xie, Yun4; Ke, Changwen5; Nie, Yifei6; Chen, Quanjiao7; Hu, Tao1; Chen, Jianjun7; Wong, Gary8,9; Wang, Qianli3; Feng, Luzhao10; Yu, Hongjie10; Liu, Yingxia8; Liu, Wenjun2; Gao, George F.2,8,10; Liu, William J.3; Shi, Weifeng1; Bi, Yuhai2,8

2019-01

10.1111/tbed.13037

Transboundary and Emerging Diseases   影响因子和分区

1865-1674

1865-1682

H6 subtype avian influenza virus (AIV) was prevalent in poultry and could sporadically infect humans. Here, a total of 196 novel H6 AIVs isolated from poultry in eight provinces of China from 2014 to 2016 were phylogenetically characterized. Our analysis revealed that they could be divided into two clades in the Asian H6 HA lineage, A/wild duck/Shantou/2853/2003(H6N2) (ST2853-like) (85.7%) and A/duck/Shantou/339/2000(H6N2) (ST339-like) (14.3%), in which ST2853-like strains predominate. These novel strains belonged to the H6N6 (n = 165, 84.2%), H6N2 (n = 30, 15.3%), and H6N3 (n = 1, 0.51%) subtypes, which could be classified into 36 genotypes including 12 novel genotypes described in this study. In particular, several strains possessed the V190 and S228 mutations in HA (H3 numbering), which is critical for human receptor binding and identical to the human-derived strain A/Taiwan/2/2013(H6N1). Furthermore, 10.3% of the H6N6 isolates possessed the N6- increment 11b (59-69) deletion. In summary, we describe phylogenetic and molecular characterizations of H6 AIVs in southern China and highlight the constant prevalence of H6 AIVs in poultry as well as adaptation to mammalian hosts.

evolution H6 subtype low pathogenic avian influenza molecular characterization reassortment

SCI

英语

通讯

Youth Innovation Promotion Association of Chinese Academy of Sciences[2017122]

Infectious Diseases ; Veterinary Sciences

Infectious Diseases ; Veterinary Sciences

WOS:000456344900064

WILEY

Web of Science

1.Taishan Med Coll, Key Lab Etiol & Epidemiol Emerging Infect Dis Sha, Tai An, Shandong, Peoples R China
2.Chinese Acad Sci, Inst Microbiol, Ctr Influenza Res & Early Warning CASCIRE, CAS Key Lab Pathogen Microbiol & Immunol, Beijing, Peoples R China
3.Chinese Ctr Dis Control & Prevent, Natl Inst Viral Dis Control & Prevent, Beijing, Peoples R China
4.Jiangxi Prov Ctr Dis Control & Prevent, Nanchang, Jiangxi, Peoples R China
5.Guangdong Prov Ctr Dis Control & Prevent, Guangzhou, Guangdong, Peoples R China
6.Henan Prov Ctr Dis Control & Prevent, Zhengzhou, Henan, Peoples R China
7.Chinese Acad Sci, Wuhan Inst Virol, CAS Key Lab Special Pathogens & Biosafety, Wuhan, Hubei, Peoples R China
8.Southern Univ Sci & Technol, Shenzhen Key Lab Pathogen & Immun, Shenzhen Peoples Hosp 3, Hosp Affiliated 2,State Key Discipline Infect Dis, Shenzhen, Peoples R China
9.Univ Laval, Dept Microbiol Infectiol & Immunol, Quebec City, PQ, Canada
10.Chinese Ctr Dis Control & Prevent, Beijing, Peoples R China

Li, Juan,Quan, Chuansong,Xie, Yun,et al. Continued reassortment of avian H6 influenza viruses from Southern China, 2014-2016[J]. Transboundary and Emerging Diseases,2019,66(1):592-598.

Li, Juan.,Quan, Chuansong.,Xie, Yun.,Ke, Changwen.,Nie, Yifei.,...&Bi, Yuhai.(2019).Continued reassortment of avian H6 influenza viruses from Southern China, 2014-2016.Transboundary and Emerging Diseases,66(1),592-598.

Li, Juan,et al."Continued reassortment of avian H6 influenza viruses from Southern China, 2014-2016".Transboundary and Emerging Diseases 66.1(2019):592-598.