| 题名 | Bruton's tyrosine kinase potentiates ALK signaling and serves as a potential therapeutic target of neuroblastoma |
| 作者 | |
| 通讯作者 | Sun, Jianmin; Zhao, Hui |
| 发表日期 | 2018-11-22
|
| DOI | |
| 发表期刊 | |
| ISSN | 0950-9232
|
| EISSN | 1476-5594
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| 卷号 | 37期号:47页码:6180-6194 |
| 摘要 | Aberrant activation of anaplastic lymphoma kinase (ALK) can cause sporadic and familial neuroblastoma. Using a proteomics approach, we identified Bruton's tyrosine kinase (BTK) as a novel ALK interaction partner, and the physical interaction was confirmed by co-immunoprecipitation. BTK is expressed in neuroblastoma cell lines and tumor tissues. Its high expression correlates with poor relapse-free survival probability of neuroblastoma patients. Mechanistically, we demonstrated that BTK potentiates ALK-mediated signaling in neuroblastoma, and increases ALK stability by reducing ALK ubiquitination. Both ALKWT and ALKF1174L can induce BTK phosphorylation and higher capacity of ALKF1174L is observed. Furthermore, the BTK inhibitor ibrutinib can effectively inhibit the growth of neuroblastoma xenograft in nude mice, and the combination of ibrutinib and the ALK inhibitor crizotinib further enhances the inhibition. Our study provides strong rationale for clinical trial of ALK-positive neuroblastoma using ibrutinib or the combination of ibrutinib and ALK inhibitors. |
| 相关链接 | [来源记录] |
| 收录类别 | |
| 语种 | 英语
|
| 学校署名 | 其他
|
| 资助项目 | National Natural Science Foundation of China[31471367]
; National Natural Science Foundation of China[31671519]
; National Natural Science Foundation of China[81660473]
|
| WOS研究方向 | Biochemistry & Molecular Biology
; Oncology
; Cell Biology
; Genetics & Heredity
|
| WOS类目 | Biochemistry & Molecular Biology
; Oncology
; Cell Biology
; Genetics & Heredity
|
| WOS记录号 | WOS:000450883000006
|
| 出版者 | |
| ESI学科分类 | MOLECULAR BIOLOGY & GENETICS
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| 来源库 | Web of Science
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| 引用统计 |
被引频次[WOS]：17
|
| 成果类型 | 期刊论文 |
| 条目标识符 | http://sustech.caswiz.com/handle/2SGJ60CL/26934 |
| 专题 | 生命科学学院_生物系 南方科技大学医学院 理学院_化学系 |
| 作者单位 | 1.Chinese Univ Hong Kong, Sch Biomed Sci, Key Lab Regenerat Med, Minist Educ,Fac Med, Hong Kong, Hong Kong, Peoples R China 2.Ningxia Med Univ, Dept Pathogen Biol & Immunol, Sch Basic Med Sci, 1160 Shengli St, Yinchuan 750004, Peoples R China 3.Southern Univ Sci & Technol, Guangdong Prov Key Lab Cell Microenvironm & Dis R, Dept Biol, Shenzhen 51805, Guangdong, Peoples R China 4.Southern Univ Sci & Technol, Shenzhen Key Lab Cell Microenvironm, Shenzhen 51805, Guangdong, Peoples R China 5.Chongqing Med Univ, Key Lab Child Dev & Disorders, Chongqing Key Lab Translat Med Res Cognit Dev & L, Dept Clin Lab,Minist Educ,Childrens Hosp,Chongqin, Chongqing 400014, Peoples R China 6.South Univ Sci & Technol China, Dept Chem, Guangdong Prov Key Lab Cell Microenvironm & Dis R, Shenzhen 518055, Guangdong, Peoples R China 7.South Univ Sci & Technol China, Shenzhen Key Lab Cell Microenvironm, Shenzhen 518055, Guangdong, Peoples R China 8.Chongqing Med Univ, Chongqing Int Sci & Technol Cooperat Ctr Child De, Key Lab Pediat Chongqing, Ctr Clin Mol Med,Childrens Hosp,Minist Educ,Key L, Chongqing 400014, Peoples R China 9.Lund Univ, Div Translat Canc Res, Dept Lab Med, Lund, Sweden 10.Chinese Univ Hong Kong, Kunming Inst Zool, Chinese Acad Sci, Joint Lab Bioresources & Mol Res Common Dis, Hong Kong, Hong Kong, Peoples R China 11.Lund Univ, Dept Lab Med, Lund Stem Cell Ctr, Lund, Sweden 12.Skane Univ Hosp, Div Oncol, Lund, Sweden |
| 推荐引用方式 GB/T 7714 |
Li, Tianfeng,Deng, Yi,Shi, Yu,et al. Bruton's tyrosine kinase potentiates ALK signaling and serves as a potential therapeutic target of neuroblastoma[J]. ONCOGENE,2018,37(47):6180-6194.
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| APA |
Li, Tianfeng.,Deng, Yi.,Shi, Yu.,Tian, Ruijun.,Chen, Yonglong.,...&Zhao, Hui.(2018).Bruton's tyrosine kinase potentiates ALK signaling and serves as a potential therapeutic target of neuroblastoma.ONCOGENE,37(47),6180-6194.
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| MLA |
Li, Tianfeng,et al."Bruton's tyrosine kinase potentiates ALK signaling and serves as a potential therapeutic target of neuroblastoma".ONCOGENE 37.47(2018):6180-6194.
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