南方科技大学知识苑(SUSTech KC): miR-26b Inhibits Virus Replication Through Positively Regulating Interferon Signaling

题名	miR-26b Inhibits Virus Replication Through Positively Regulating Interferon Signaling
作者	Liu, Chang1,2,3 ; Zhang, Liting 1,2; Xu, Rui 1,2; Zheng, Hui 1,2
通讯作者	Liu, Chang; Zheng, Hui
发表日期	2018-09-28
DOI	10.1089/vim.2018.0067
发表期刊	VIRAL IMMUNOLOGY 影响因子和分区
ISSN	0882-8245
EISSN	1557-8976
卷号	31 期号:10页码:676-682
摘要	microRNAs have been reported to play crucial roles in various biological processes, including cell proliferation, apoptosis, tumor genesis, and viral infections. miR-26b has been found to be involved in the pathogenesis of multiple tumors, however, little is known about the role it plays in innate immune responses. In this study, we report that miR-26b is able to induce type-I interferon (IFN) expression, which was supported by both quantitative real time polymerase chain reaction and luciferase reporter assays. Conversely, production of IFN was reduced upon inhibition of miR-26b. Sequentially, ectopic expression of miR-26b led to upregulated expression of STAT1 and IFN-stimulated genes (ISGs). Furthermore, overexpression of miR-26b repressed the replication of vesicular stomatitis virus (VSV) and Sendai virus (SeV). In turn, IFN was able to induce the expression of miR-26b in a time-dependent manner. In all, we found that miR-26b could inhibit VSV replication through upregulation of type-I IFNs and ISGs and could in turn be upregulated by IFNs.
关键词	miRNA miR-26b innate immune response IFN
相关链接	[来源记录]
收录类别	SCI
语种	英语
学校署名	通讯
资助项目	program for Changjiang scholars and Innovative Research Team in the University of Ministry of Education of China[PCSIRT-IRT1075]
WOS研究方向	Immunology ; Virology
WOS类目	Immunology ; Virology
WOS记录号	WOS:000445878500001
出版者	MARY ANN LIEBERT, INC
ESI学科分类	IMMUNOLOGY
来源库	Web of Science
引用统计	被引频次[WOS]：6
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/27205
专题	生命科学学院_生物系
作者单位	1.Soochow Univ, Inst Biol, 199 Renai Rd, Suzhou 215123, Jiangsu, Peoples R China 2.Soochow Univ, Inst Med Sci, 199 Renai Rd, Suzhou 215123, Jiangsu, Peoples R China 3.South Univ Sci & Technol, Dept Biol, 1088 Xueyuan Blvd, Shenzhen 518055, Guangdong, Peoples R China
第一作者单位	生物系
通讯作者单位	生物系
推荐引用方式 GB/T 7714	Liu, Chang,Zhang, Liting,Xu, Rui,et al. miR-26b Inhibits Virus Replication Through Positively Regulating Interferon Signaling[J]. VIRAL IMMUNOLOGY,2018,31(10):676-682.
APA	Liu, Chang,Zhang, Liting,Xu, Rui,&Zheng, Hui.(2018).miR-26b Inhibits Virus Replication Through Positively Regulating Interferon Signaling.VIRAL IMMUNOLOGY,31(10),676-682.
MLA	Liu, Chang,et al."miR-26b Inhibits Virus Replication Through Positively Regulating Interferon Signaling".VIRAL IMMUNOLOGY 31.10(2018):676-682.