A Mitochondria-Associated Oxidative Stress Perspective on Huntington's Disease

Zheng, Ju1,2,3; Winderickx, Joris2; Franssens, Vanessa2; Liu, Beidong3,4,5

2018-09-19

10.3389/fnmol.2018.00329

Frontiers in Molecular Neuroscience   影响因子和分区

1662-5099

Huntington's disease (HD) is genetically caused by mutation of the Huntingtin (HTT) gene. At present, the mechanisms underlying the defect of HTT and the development of HD remain largely unclear. However, increasing evidence shows the presence of enhanced oxidative stress in HD patients. In this review article, we focus on the role of oxidative stress in the pathogenesis of HD and discuss mediators and potential mechanisms involved in mutant HTT-mediated oxidative stress generation and progression. Furthermore, we emphasize the role of the unicellular organism Saccharomyces cerevisiae in investigating mutant HTT-induced oxidative stress. Overall, this review article provides an overview of the latest findings regarding oxidative stress in HD and potential therapeutic targets for HD.

Huntington's disease Huntingtin neurodegeneration yeast oxidative stress

SCI

英语

第一

People Programme (Marie Curie Actions) of the European Union's Seventh Framework Programme (FP7/2007-2013) under REA[608743]

Neurosciences & Neurology

Neurosciences

WOS:000445070100001

FRONTIERS MEDIA SA

Web of Science

1.Southern Univ Sci & Technol, Dept Biol, Shenzhen, Peoples R China
2.Katholieke Univ Leuven, Dept Biol, Funct Biol, Heverlee, Belgium
3.Univ Gothenburg, Dept Chem & Mol Biol, Gothenburg, Sweden
4.Zhejiang A&F Univ, Sch Forestry & Biotechnol, State Key Lab Subtrop Silviculture, Hangzhou, Zhejiang, Peoples R China
5.Univ Gothenburg, Ctr Large Scale Cell Based Screening, Fac Sci, Gothenburg, Sweden

Zheng, Ju,Winderickx, Joris,Franssens, Vanessa,et al. A Mitochondria-Associated Oxidative Stress Perspective on Huntington's Disease[J]. Frontiers in Molecular Neuroscience,2018,11.

Zheng, Ju,Winderickx, Joris,Franssens, Vanessa,&Liu, Beidong.(2018).A Mitochondria-Associated Oxidative Stress Perspective on Huntington's Disease.Frontiers in Molecular Neuroscience,11.

Zheng, Ju,et al."A Mitochondria-Associated Oxidative Stress Perspective on Huntington's Disease".Frontiers in Molecular Neuroscience 11(2018).