Classification of Cognitive Impairment and Healthy Controls Based on Transcranial Magnetic Stimulation Evoked Potentials

Zhang, Jiahao1,2; Lu, Haifeng3; Zhu, Lin4; Ren, Huixia5,6; Dang, Ge4; Su, Xiaolin4; Lan, Xiaoyong4; Jiang, Xin7; Zhang, Xu1,2; Feng, Jiansong1,2; Shi, Xue4; Wang, Taihong1,2; Hu, Xiping3,8; Guo, Yi4,9

2021-12-24

10.3389/fnagi.2021.804384

Frontiers in Aging Neuroscience   影响因子和分区

1663-4365

Backgrounds: Nowadays, risks of Cognitive Impairment (CI) [highly suspected Alzheimer's disease (AD) in this study] threaten the quality of life for more older adults as the population ages. The emergence of Transcranial Magnetic Stimulation-Electroencephalogram (TMS-EEG) enables noninvasive neurophysiological investi-gation of the human cortex, which might be potentially used for CI detection.Objectives: The aim of this study is to explore whether the spatiotemporal features of TMS Evoked Potentials (TEPs) could classify CI from healthy controls (HC).Methods: Twenty-one patients with CI and 22 HC underwent a single-pulse TMS-EEG stimulus in which the pulses were delivered to the left dorsolateral prefrontal cortex (left DLPFC). After preprocessing, seven regions of interest (ROIs) and two most reliable TEPs' components: N100 and P200 were selected. Next, seven simple and interpretable linear features of TEPs were extracted for each region, three common machine learning algorithms including Support Vector Machine (SVM), Random Forest (RF), and K-Nearest Neighbor (KNN) were used to detect CI. Meanwhile, data augmentation and voting strategy were used for a more robust model. Finally, the performance differences of features in classifiers and their contributions were investigated.Results: 1. In the time domain, the features of N100 had the best performance in the SVM classifier, with an accuracy of 88.37%. 2. In the aspect of spatiality, the features of the right frontal region and left parietal region had the best performance in the SVM classifier, with an accuracy of 83.72%. 3. The Local Mean Field Power (LMFP), Average Value (AVG), Latency and Amplitude contributed most in classification.Conclusions: The TEPs induced by TMS over the left DLPFC has significant differences spatially and temporally between CI and HC. Machine learning based on the spatiotemporal features of TEPs have the ability to separate the CI and HC which suggest that TEPs has potential as non-invasive biomarkers for CI diagnosis.

spatiotemporal features machine learning cognitive impairment TEP TMS-EEG

SCI

英语

第一 ; 通讯

Shenzhen Science and Technology Innovation Commission["KCXFZ20201221173400001","KCXFZ20201221173411032"] ; Natural Science Fund of Guangdong Province[2021A1515010983] ; Shenzhen Key Medical Discipline Construction Fund[SZXK005] ; Special Funds for the Cultivation of Guangdong College Students' Scientific and Technological Innovation (Climbing Program Special Funds)[pdjh2021c0018]

Geriatrics & Gerontology ; Neurosciences & Neurology

Geriatrics & Gerontology ; Neurosciences

WOS:000741809600001

FRONTIERS MEDIA SA

Web of Science

1.Southern Univ Sci & Technol, Dept Elect & Elect Engn, Shenzhen, Peoples R China
2.Southern Univ Sci & Technol, Sch Microelectron, Shenzhen, Peoples R China
3.Lanzhou Univ, Sch Informat Sci & Engn, Gansu Prov Key Lab Wearable Comp, Lanzhou, Peoples R China
4.Jinan Univ, Clin Med Coll 2, Southern Univ Sci & Technol,Affiliated Hosp 1, Dept Neurol,Shenzhen Peoples Hosp, Shenzhen, Peoples R China
5.Jinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Dept Neurol, Shenzhen, Peoples R China
6.Jinan Univ, Affiliated Hosp 1, Guangzhou, Peoples R China
7.Jinan Univ, Clin Med Coll 2, Southern Univ Sci & Technol,Dept Gerat, Shenzhen Peoples Hosp,Affiliated Hosp 1, Shenzhen, Peoples R China
8.Sun Yat Sen Univ, Sch Intelligent Syst Engn, Shenzhen, Peoples R China
9.Shenzhen Bay Lab, Shenzhen, Peoples R China

Zhang, Jiahao,Lu, Haifeng,Zhu, Lin,et al. Classification of Cognitive Impairment and Healthy Controls Based on Transcranial Magnetic Stimulation Evoked Potentials[J]. Frontiers in Aging Neuroscience,2021,13.

Zhang, Jiahao.,Lu, Haifeng.,Zhu, Lin.,Ren, Huixia.,Dang, Ge.,...&Guo, Yi.(2021).Classification of Cognitive Impairment and Healthy Controls Based on Transcranial Magnetic Stimulation Evoked Potentials.Frontiers in Aging Neuroscience,13.

Zhang, Jiahao,et al."Classification of Cognitive Impairment and Healthy Controls Based on Transcranial Magnetic Stimulation Evoked Potentials".Frontiers in Aging Neuroscience 13(2021).