南方科技大学知识苑(SUSTech KC): The Hippo pathway kinases LATS1 and LATS2 attenuate cellular responses to heavy metals through phosphorylating MTF1

题名	The Hippo pathway kinases LATS1 and LATS2 attenuate cellular responses to heavy metals through phosphorylating MTF1
作者	Han, Han 1; Nakaoka, Hiroki J.1; Hofmann, Line 1; Zhou, Jeff Jiajing 1; Yu, Clinton 2; Zeng, Lisha 3; Nan, Junyu 3; Seo, Gayoung 1; Vargas, Rebecca Elizabeth 1; Yang, Bing 1; Qi, Ruxi4 ; Bardwell, Lee 1; Fishman, Dmitry A.5; Cho, Ken W. Y.1; Huang, Lan 2; Luo, Ray 3,6,7,8; Warrior, Rahul 1; Wang, Wenqi 1
通讯作者	Warrior, Rahul; Wang, Wenqi
发表日期	2022
DOI	10.1038/s41556-021-00813-8
发表期刊	NATURE CELL BIOLOGY 影响因子和分区
ISSN	1465-7392
EISSN	1476-4679
摘要	["Han et al. report that the Hippo pathway kinases LATS1 and LATS2 phosphorylate the heavy metal response transcription factor MTF1, leading to attenuation of heavy metal response gene transcription and cellular detoxification.","Heavy metals are both integral parts of cells and environmental toxicants, and their deregulation is associated with severe cellular dysfunction and various diseases. Here we show that the Hippo pathway plays a critical role in regulating heavy metal homeostasis. Hippo signalling deficiency promotes the transcription of heavy metal response genes and protects cells from heavy metal-induced toxicity, a process independent of its classic downstream effectors YAP and TAZ. Mechanistically, the Hippo pathway kinase LATS phosphorylates and inhibits MTF1, an essential transcription factor in the heavy metal response, resulting in the loss of heavy metal response gene transcription and cellular protection. Moreover, LATS activity is inhibited following heavy metal treatment, where accumulated zinc directly binds and inhibits LATS. Together, our study reveals an interplay between the Hippo pathway and heavy metals, providing insights into this growth-related pathway in tissue homeostasis and stress response."]
相关链接	[来源记录]
收录类别	SCI
语种	英语
重要成果	NI论文
学校署名	其他
资助项目	NIH["R01GM126048","R21ES031642","R35GM130367","R35GM139617","R01GM130144"] ; American Cancer Society Research Scholar grant[RSG-18-009-01-CCG] ; University of California Cancer Research Coordinating Committee Research Award[CRN-19585568]
WOS研究方向	Cell Biology
WOS类目	Cell Biology
WOS记录号	WOS:000742323100004
出版者	NATURE PORTFOLIO
ESI学科分类	MOLECULAR BIOLOGY & GENETICS
来源库	Web of Science
引用统计	被引频次[WOS]：34
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/272303
专题	南方科技大学冷冻电镜中心
作者单位	1.Univ Calif Irvine, Dept Dev & Cell Biol, Irvine, CA 92717 USA 2.Univ Calif Irvine, Dept Physiol & Biophys, Irvine, CA 92717 USA 3.Univ Calif Irvine, Dept Mol Biol & Biochem, Irvine, CA 92717 USA 4.Southern Univ Sci & Technol, Cryo EM Ctr, Shenzhen, Peoples R China 5.Univ Calif Irvine, Dept Chem, Irvine, CA 92717 USA 6.Univ Calif Irvine, Dept Chem & Biomol Engn, Irvine, CA USA 7.Univ Calif Irvine, Dept Mat Sci & Engn, Irvine, CA USA 8.Univ Calif Irvine, Dept Biomed Engn, Irvine, CA USA
推荐引用方式 GB/T 7714	Han, Han,Nakaoka, Hiroki J.,Hofmann, Line,et al. The Hippo pathway kinases LATS1 and LATS2 attenuate cellular responses to heavy metals through phosphorylating MTF1[J]. NATURE CELL BIOLOGY,2022.
APA	Han, Han.,Nakaoka, Hiroki J..,Hofmann, Line.,Zhou, Jeff Jiajing.,Yu, Clinton.,...&Wang, Wenqi.(2022).The Hippo pathway kinases LATS1 and LATS2 attenuate cellular responses to heavy metals through phosphorylating MTF1.NATURE CELL BIOLOGY.
MLA	Han, Han,et al."The Hippo pathway kinases LATS1 and LATS2 attenuate cellular responses to heavy metals through phosphorylating MTF1".NATURE CELL BIOLOGY (2022).