| 题名 | Asymmetric phosphoric acid-catalyzed four-component Ugi reaction |
| 作者 | |
| 通讯作者 | Houk, Kendall N.; Tan, Bin |
| 发表日期 | 2018-09-14
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| DOI | |
| 发表期刊 | |
| ISSN | 0036-8075
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| EISSN | 1095-9203
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| 卷号 | 361期号:6407页码:1087-+ |
| 摘要 | The Ugi reaction constructs alpha-acylaminoamide compounds by combining an aldehyde or ketone, an amine, a carboxylic acid, and an isocyanide in a single flask. Its appealing features include inherent atom and step economy together with the potential to generate products of broad structural diversity. However, control of the stereochemistry in this reaction has proven to be a formidable challenge. We describe an efficient enantioselective four-component Ugi reaction catalyzed by a chiral phosphoric acid derivative that delivers more than 80 alpha-acylaminoamides in good to excellent enantiomeric excess. Experimental and computational studies establish the reaction mechanism and origins of stereoselectivity. |
| 相关链接 | [来源记录] |
| 收录类别 | |
| 语种 | 英语
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| 重要成果 | NI期刊
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| 学校署名 | 第一
; 通讯
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| 资助项目 | NSF[OCI-1053575]
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| WOS研究方向 | Science & Technology - Other Topics
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| WOS类目 | Multidisciplinary Sciences
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| WOS记录号 | WOS:000444513300032
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| 出版者 | |
| ESI学科分类 | BIOLOGY & BIOCHEMISTRY;CLINICAL MEDICINE;MULTIDISCIPLINARY;PLANT & ANIMAL SCIENCE;ENVIRONMENT/ECOLOGY;SOCIAL SCIENCES, GENERAL;MICROBIOLOGY;ECONOMICS BUSINESS;IMMUNOLOGY;MATERIALS SCIENCE;MATHEMATICS;COMPUTER SCIENCE;SPACE SCIENCE;MOLECULAR BIOLOGY & GENETICS;CHEMISTRY;PSYCHIATRY/PSYCHOLOGY;NEUROSCIENCE & BEHAVIOR;PHYSICS;GEOSCIENCES;ENGINEERING
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| 来源库 | Web of Science
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| 引用统计 |
被引频次[WOS]：164
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| 成果类型 | 期刊论文 |
| 条目标识符 | http://sustech.caswiz.com/handle/2SGJ60CL/27233 |
| 专题 | 理学院_化学系 深圳格拉布斯研究院 |
| 作者单位 | 1.Southern Univ Sci & Technol, Shenzhen Grubbs Inst, Dept Chem, Shenzhen 518055, Peoples R China 2.Univ Calif Los Angeles, Dept Chem & Biochem, Los Angeles, CA 90095 USA |
| 第一作者单位 | 化学系; 深圳格拉布斯研究院 |
| 通讯作者单位 | 化学系; 深圳格拉布斯研究院 |
| 第一作者的第一单位 | 化学系; 深圳格拉布斯研究院 |
| 推荐引用方式 GB/T 7714 |
Zhang, Jian,Yu, Peiyuan,Li, Shao-Yu,et al. Asymmetric phosphoric acid-catalyzed four-component Ugi reaction[J]. SCIENCE,2018,361(6407):1087-+.
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| APA |
Zhang, Jian.,Yu, Peiyuan.,Li, Shao-Yu.,Sun, He.,Xiang, Shao-Hua.,...&Tan, Bin.(2018).Asymmetric phosphoric acid-catalyzed four-component Ugi reaction.SCIENCE,361(6407),1087-+.
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| MLA |
Zhang, Jian,et al."Asymmetric phosphoric acid-catalyzed four-component Ugi reaction".SCIENCE 361.6407(2018):1087-+.
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| 条目包含的文件 | 条目无相关文件。 | |||||
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